Abstract

We have tested several novel modulators that target the pathways relevant to ionizing radiation and metabolism. We have used clonogenic survival assays of human tumor cells in vitro to characterize the temporal components and dose-dependency of the response to ionizing radiation. We have also begun testing these modulators in in vivo xenograft models to determine the correlation with our in vitro results. We have also begun investigating potential mechanisms and related pathways in order to better understand our results.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011575-05
Application #
9779965
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Kambach, Diane M; Halim, Alan S; Cauer, A Gesine et al. (2017) Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma. Oncotarget 8:14860-14875
Kesarwala, A H; Krishna, M C; Mitchell, J B (2016) Oxidative stress in oral diseases. Oral Dis 22:9-18
Ma, Chi; Kesarwala, Aparna H; Eggert, Tobias et al. (2016) NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature 531:253-7
Ridnour, Lisa A; Cheng, Robert Y S; Weiss, Jonathan M et al. (2015) NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res 75:2788-99
Kesarwala, Aparna H; Ko, Christine J; Ning, Holly et al. (2015) Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in the definitive treatment of locally advanced non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer 16:237-44
Cheng, Robert Y S; Basudhar, Debashree; Ridnour, Lisa A et al. (2014) Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways. Nitric Oxide 43:17-28