Abstract

Over the past several years, our group has been focused on studying genes with neuromodulatory, neuroprotective and/or neuroregenerative effects in models of neurodegeneration and neurotoxicity. We primarily have examined how the MANF/CDNF protein family can improve neuronal survival during injury or disease states. We published paper showing MANF has protective effects when administered after stroke. In collaboration with Dr. Airavaara (U Helsinki), we examined the neuroprotective actions of two isoforms of the dopaminergic neurotrophic factor, GDNF. This work is now published in Frontiers of Neurology. In collaboration with Yun Wang (NHRI, Taiwan) we demonstrate how 9-cis retinoic acid promotes neurorepair through the action of trophic factors and improves the recovery from an ischemic injury in a rat model of stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000443-18
Application #
9776059
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Mätlik, Kert; Anttila, Jenni E; Kuan-Yin, Tseng et al. (2018) Poststroke delivery of MANF promotes functional recovery in rats. Sci Adv 4:eaap8957
Anttila, Jenni E; Albert, Katrina; Wires, Emily S et al. (2018) Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. eNeuro 5:
Song, Kang-Ho; Fan, Alexander C; Hinkle, Joshua J et al. (2017) Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Theranostics 7:144-152
Wallace, Veronica J; Cimbro, Raffaello; Rubio, F Javier et al. (2017) Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres. Cell Mol Neurobiol 37:1487-1499
Koskela, Maryna; Bäck, Susanne; Võikar, Vootele et al. (2017) Update of neurotrophic factors in neurobiology of addiction and future directions. Neurobiol Dis 97:189-200
Howard, Douglas B; Harvey, Brandon K (2017) Assaying the Stability and Inactivation of AAV Serotype 1 Vectors. Hum Gene Ther Methods 28:39-48
Anttila, Jenni E; Whitaker, Keith W; Wires, Emily S et al. (2017) Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Prog Neuropsychopharmacol Biol Psychiatry 79:3-14
Wires, Emily S; Henderson, Mark J; Yan, Xiaokang et al. (2017) Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo. PLoS One 12:e0175481
Richie, Christopher T; Whitaker, Leslie R; Whitaker, Keith W et al. (2017) Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies. J Neurosci Methods 284:1-14
Yu, Seong-Jin; Airavaara, Mikko; Wu, Kuo-Jen et al. (2017) 9-cis retinoic acid induces neurorepair in stroke brain. Sci Rep 7:4512

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