Over the past several years, our group has been focused on studying genes with neuromodulatory, neuroprotective and/or neuroregenerative effects in models of neurodegeneration and neurotoxicity. We primarily have examined how the MANF/CDNF protein family can improve neuronal survival during injury or disease states. We published paper showing MANF has protective effects when administered after stroke. Our lab discovered that the cytomegaloviral promoter commonly used in viral vectors for gene delivery studies as well as clinical trials in humans is affected by various forms of neuronal activation. This work is published in Mol Ther Methods Clin Dev. In collaboration with Dr. Mark Borden(CU Bolder), we described the state of the art for using focused ultrasound with microbubbles for disrupting the blood brain barrier towards non-invasive gene delivery. This was published in Theranostics. In collaboration with Mikko Airavaara (U Helsinki) we identified an experimental caveat when using AAV vectors in rodent models of Parkinson's disease. This work is published in J Neurosci Res.

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National Institute on Drug Abuse
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Mätlik, Kert; Anttila, Jenni E; Kuan-Yin, Tseng et al. (2018) Poststroke delivery of MANF promotes functional recovery in rats. Sci Adv 4:eaap8957
Anttila, Jenni E; Albert, Katrina; Wires, Emily S et al. (2018) Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. eNeuro 5:
Yu, Seong-Jin; Airavaara, Mikko; Wu, Kuo-Jen et al. (2017) 9-cis retinoic acid induces neurorepair in stroke brain. Sci Rep 7:4512
Baldwin, Heather A; Koivula, Pyry P; Necarsulmer, Julie C et al. (2017) Step Sequence Is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models. Cell Transplant 26:659-667
Song, Kang-Ho; Fan, Alexander C; Hinkle, Joshua J et al. (2017) Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Theranostics 7:144-152
Wallace, Veronica J; Cimbro, Raffaello; Rubio, F Javier et al. (2017) Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres. Cell Mol Neurobiol 37:1487-1499
Koskela, Maryna; Bäck, Susanne; Võikar, Vootele et al. (2017) Update of neurotrophic factors in neurobiology of addiction and future directions. Neurobiol Dis 97:189-200
Howard, Douglas B; Harvey, Brandon K (2017) Assaying the Stability and Inactivation of AAV Serotype 1 Vectors. Hum Gene Ther Methods 28:39-48
Anttila, Jenni E; Whitaker, Keith W; Wires, Emily S et al. (2017) Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Prog Neuropsychopharmacol Biol Psychiatry 79:3-14
Wires, Emily S; Henderson, Mark J; Yan, Xiaokang et al. (2017) Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo. PLoS One 12:e0175481

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