During this year, we reported additional genome wide association for smoking cessation success in data from additional clincal trial participants in the United States and United Kingdom. We completed work on application of this work to prospective samples of clinical trial participants, and reported the exciting findings from this work. We reported models for the impressive effect on knowing quit success genes on the power of mid-sized clinical trials for smoking cessation. Smoking quit success genes identified in this fashion include a modest number of genes that we have identified in studies of addiction vulnerability. A sizable number of these genes have products that are involved in cell adhesion molecule actions. Several are likely to be involved in learning and memory mechanisms. These promising results, now obtained from seven independent samples, are allowing us to predict who might be more or less likely to succeed in quitting, in ways that may provide better targeting of antismoking therapeutics in the relatively near future.

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National Institute on Drug Abuse
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Musci, Rashelle J; Masyn, Katherine E; Benke, Kelly et al. (2016) The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence. Dev Psychopathol 28:225-37
Stein, Renee; Shapatava, Ekaterine; Williams, Weston et al. (2015) Reduced Sexual Risk Behaviors Among Young Men of Color Who Have Sex with Men: Findings from the Community-Based Organization Behavioral Outcomes of Many Men, Many Voices (CBOP-3MV) Project. Prev Sci 16:1147-58
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Musci, Rashelle J; Bradshaw, Catherine P; Maher, Brion et al. (2014) Erratum to: Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction. Prev Sci :
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Musci, Rashelle J; Bradshaw, Catherine P; Maher, Brion et al. (2014) Reducing aggression and impulsivity through school-based prevention programs: a gene by intervention interaction. Prev Sci 15:831-40
Uhl, G R; Walther, D; Musci, R et al. (2014) Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. Mol Psychiatry 19:50-4
Bough, K J; Lerman, C; Rose, J E et al. (2013) Biomarkers for smoking cessation. Clin Pharmacol Ther 93:526-38

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