We have generated and analyzed the effects of muscle-specific inhibition of myostatin signaling in an obese hyperglycemic mouse model. We have measured energy intake and energy expenditure, muscle and fat weights and histology, and performed analysis of glucose metabolism in these mice. We have also analyzed blood glucose and glucose and insulin tolerance after myostatin inhibition in other mouse models of diabetes to determine which types of diabetes might be ameliorated by myostatin inhibition.

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McPherron, Alexandra C; Guo, Tingqing; Bond, Nichole D et al. (2013) Increasing muscle mass to improve metabolism. Adipocyte 2:92-8
McPherron, A C; Guo, T; Wang, Q et al. (2012) Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity. Diabetes Obes Metab 14:279-82
Guo, Tingqing; Bond, Nichole D; Jou, William et al. (2012) Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy. Diabetes 61:2414-23
Allen, David L; Hittel, Dustin S; McPherron, Alexandra C (2011) Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Med Sci Sports Exerc 43:1828-35
McPherron, Alexandra C (2010) METABOLIC FUNCTIONS OF MYOSTATIN AND GDF11. Immunol Endocr Metab Agents Med Chem 10:217-231