We have generated and analyzed the effects of muscle-specific inhibition of myostatin signaling in mice made obese by high-fat diet feeding. These results show that myostatin inhibition after obesity has developed does not cause weight loss. We have also analyzed blood glucose and glucose and insulin tolerance after myostatin inhibition in other mouse models of diabetes to determine which types of diabetes might be ameliorated by myostatin inhibition. Increasing muscle hypertrophy in a mouse model of lipodystrophic diabetes prevents the development of hyperglycemia and lipidemia. These results show that myostatin inhibition does not improve glucose metabolism solely by preventing obesity.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
McPherron, Alexandra C; Guo, Tingqing; Bond, Nichole D et al. (2013) Increasing muscle mass to improve metabolism. Adipocyte 2:92-8
McPherron, A C; Guo, T; Wang, Q et al. (2012) Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity. Diabetes Obes Metab 14:279-82
Guo, Tingqing; Bond, Nichole D; Jou, William et al. (2012) Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy. Diabetes 61:2414-23
Allen, David L; Hittel, Dustin S; McPherron, Alexandra C (2011) Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Med Sci Sports Exerc 43:1828-35
McPherron, Alexandra C (2010) METABOLIC FUNCTIONS OF MYOSTATIN AND GDF11. Immunol Endocr Metab Agents Med Chem 10:217-231