We have recently guided the data analysis for several projects, primarily involving data from the Agricultural Health Study (AHS), a cohort of licensed pesticide applicators (mostly farmers) from Iowa and North Carolina. One project probed a possible relationship between pesticide exposure and depression among male private applicators in the AHS. We used inverse probability weighting to account for exclusions due to missing data and polytomous logistic regression to estimate odds ratios. Ever use of fumigants as a class and several individual pesticides were associated with depression. Using data from the AHS, we have also studied whether farming exposures contribute to exacerbation of asthma. We noted inverse association of asthma with several farming activities and with ever use of two herbicides but no positive associations (except in a subset of cases with asthma and allergy). These observations are consistent with the possibility that asthma cases prone to exacerbation tend to avoid exposures that trigger symptoms. Farmers have different respiratory exposures and, consequently, different respiratory risks than the general population;yet few studies have been able to compare farmers with a corresponding general population. We compared the prevalence of self-reported respiratory outcomes for participants in the AHS with data from adults who participated in the National Health and Nutrition Examination Survey (NHANES) over the same time period. Farmers in the AHS had lower prevalence of respiratory diseases such as asthma, chronic bronchitis, and emphysema but higher prevalence of respiratory symptoms such as wheeze, cough, and phlegm compared to NHANES adults after controlling for smoking and other characteristics that differed between the two populations. Investigation of other aspects of the epidemiology of respiratory disease and symptoms in relationship to farming exposures, including pesticides, is continuing. A last project using data from the AHS examined the possible relationship between diabetes and ever use of specific pesticides before enrollment. Using age as the time scale and diagnosis with diabetes as the event of interest, we fit Cox proportional hazards models to estimate hazard ratios. Ever use of five pesticides (three of them organophosphates) were associated with diabetes among farmers wives who reported ever mixing or applying pesticides.
| Shrestha, Srishti; Parks, Christine G; Goldner, Whitney S et al. (2018) Incident thyroid disease in female spouses of private pesticide applicators. Environ Int 118:282-292 |
| Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001 |
| Bernhardt, Miranda L; Stein, Paula; Carvacho, Ingrid et al. (2018) TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization. Proc Natl Acad Sci U S A 115:E10370-E10378 |
| Wyss, Annah B; House, John S; Hoppin, Jane A et al. (2018) Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax 73:279-282 |
| Baumert, Brittney O; Carnes, Megan Ulmer; Hoppin, Jane A et al. (2018) Sleep apnea and pesticide exposure in a study of US farmers. Sleep Health 4:20-26 |
| Li, Yuanyuan; Umbach, David M; Li, Leping (2017) Putative genomic characteristics of BRAF V600K versus V600E cutaneous melanoma. Melanoma Res 27:527-535 |
| Hoppin, Jane A; Umbach, David M; Long, Stuart et al. (2017) Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers. Environ Health Perspect 125:535-543 |
| Beard, John D; Engel, Lawrence S; Richardson, David B et al. (2017) Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival. PLoS One 12:e0185751 |
| House, John S; Wyss, Annah B; Hoppin, Jane A et al. (2017) Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol 140:249-256.e14 |
| Carnes, Megan Ulmer; Hoppin, Jane A; Metwali, Nervana et al. (2017) House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population. Ann Am Thorac Soc 14:324-331 |
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