We have recently guided the data analysis for several projects, primarily involving data from the Agricultural Health Study (AHS), a cohort of licensed pesticide applicators (mostly farmers) from Iowa and North Carolina. We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the AHS. We used Cox proportional hazards models to estimate hazard ratios for associations between pesticide use at enrollment (19931997) and hyperthyroidism (n=271) among 35,150 applicators (mostly men) adjusting for potential confounders. Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine) was associated with reduced risk of hyperthyroidism; hazard ratios ranged from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. These results require confirmation in additional studies. Olfactory impairment is common among older adults and predictive of risk for certain neurodegenerative diseases. We examined high pesticide exposure events (HPEEs) reported at enrollment in relation to self-reported olfactory impairment at the latest AHS follow-up (20132015) using multivariable logistic regression considering farmers without HPEEs as unexposed. About 10.6% of farmers reported olfactory impairment. A history of HPEEs was associated with a higher likelihood of reporting olfactory impairment two decades later odds ratio (OR)=1:49 95% confidence interval (CI):1.28,1.73. The association appeared stronger the longer the delay between an HPEE and washing with soap and water e.g., OR=2:07 (95% CI: 1.48, 2.89) for 46 hrs. OR=1:39 (95%CI: 1.11, 1.75) for <30min. Our study was limited by use of self-reported olfactory impairment; future studies should assess olfactory impairment objectively. In earlier work, we reported lower mortality rates through 2007 among AHS participants compared to the general population. We extended the mortality analysis among AHS participants in three subgroups(51,502 private pesticide applicators, their 31,867 spouses, and 4,677 commercial pesticide applicators in Iowa and North Carolina) through 2015. In addition, we compared results using several analytic approaches (standardized mortality ratios (SMRs), causal mortality ratios (CMRs), and relative SMRs) using state-specific mortality rates of the general populations as the referent. Over the average 16 years of follow-up, 9,305 private applicators, 3,384 spouses, and 415 commercial applicators died. SMRs and CMRs indicated lower overall mortality in all three study subgroups (SMRs ranging 0.610.69 and CMRs 0.740.89. SMR analyses indicated fewer-than-expected deaths from many causes, but greater-then-expected deaths from transportation-related injuries and mechanical forces were elevated in private applicators. CMRs indicated higher-than-expected deaths from prostate cancer, lymphohematopoietic cancers, Parkinsons and Alzheimers disease, and chronic glomerulonephritis in private applicators, and non-Hodgkin lymphoma in spouses (ranging 1.191.53). Relative SMR and CMR provided comparable findings.
| Shrestha, Srishti; Parks, Christine G; Goldner, Whitney S et al. (2018) Incident thyroid disease in female spouses of private pesticide applicators. Environ Int 118:282-292 |
| Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001 |
| Bernhardt, Miranda L; Stein, Paula; Carvacho, Ingrid et al. (2018) TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization. Proc Natl Acad Sci U S A 115:E10370-E10378 |
| Wyss, Annah B; House, John S; Hoppin, Jane A et al. (2018) Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax 73:279-282 |
| Baumert, Brittney O; Carnes, Megan Ulmer; Hoppin, Jane A et al. (2018) Sleep apnea and pesticide exposure in a study of US farmers. Sleep Health 4:20-26 |
| House, John S; Wyss, Annah B; Hoppin, Jane A et al. (2017) Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol 140:249-256.e14 |
| Carnes, Megan Ulmer; Hoppin, Jane A; Metwali, Nervana et al. (2017) House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population. Ann Am Thorac Soc 14:324-331 |
| Li, Yuanyuan; Umbach, David M; Li, Leping (2017) Putative genomic characteristics of BRAF V600K versus V600E cutaneous melanoma. Melanoma Res 27:527-535 |
| Hoppin, Jane A; Umbach, David M; Long, Stuart et al. (2017) Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers. Environ Health Perspect 125:535-543 |
| Beard, John D; Engel, Lawrence S; Richardson, David B et al. (2017) Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival. PLoS One 12:e0185751 |
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