Abstract

The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES103318-02
Application #
9550224
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Li, Ruifang; Grimm, Sara A; Mav, Deepak et al. (2018) Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer. Cell Rep 22:624-637
Merrick, B Alex; Chang, Justin S; Phadke, Dhiral P et al. (2018) HAfTs are novel lncRNA transcripts from aflatoxin exposure. PLoS One 13:e0190992
Bryce, Steven M; Bernacki, Derek T; Smith-Roe, Stephanie L et al. (2018) Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals. Toxicol Sci 162:146-166
Auerbach, Scott S; Xu, Miaofei; Merrick, B Alex et al. (2018) Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure. Toxicol Pathol 46:706-718
Mav, Deepak; Shah, Ruchir R; Howard, Brian E et al. (2018) A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics. PLoS One 13:e0191105
Xia, Menghang; Huang, Ruili; Shi, Qiang et al. (2018) Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environ Health Perspect 126:077010
Myatt, Glenn J; Ahlberg, Ernst; Akahori, Yumi et al. (2018) In silico toxicology protocols. Regul Toxicol Pharmacol 96:1-17
Kleinstreuer, Nicole C; Hoffmann, Sebastian; Alépée, Nathalie et al. (2018) Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *. Crit Rev Toxicol 48:359-374
Dunnick, J K; Pandiri, A R; Merrick, B A et al. (2018) Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice. Toxicol Rep 5:615-624
Smith-Roe, Stephanie L; Swartz, Carol D; Shepard, Kim G et al. (2018) Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells. Environ Mol Mutagen 59:416-426

Showing the most recent 10 out of 79 publications