We investigated the incidence and prevalence of retinopathy in a sample of 981 middle-aged ARIC study participants who were selected to participate in the third and fourth ARIC study examinations and who had retinal photographs of the same eye taken at both study visits. The prevalence of retinopathy was 7.7%, with 3.8% of people developing signs of retinopathy in the three year interval between exams. Although the rate of retinopathy was found to be higher among diabetics (40 of 147), a comparable number of cases occurred in non-diabetic individuals (36 of 834). Factors found to increase risk of retinopathy include higher levels of blood pressure, fasting serum glucose, total cholesterol, and plasma fibrinogen. We examined 10 year changed in retinal microvascular lesions in a sample of ARIC participants and found that, over a decade, new retinal vessels appeared and a significant proportion disappeared, suggesting considerable remodeling in the retinal microvasculature. Specific data analysis of ocular phenotypes in conjunction with genotype data continues within the CHARGE Consortium. See PLOS Genetics Oct 2010 e1001184. Building on findings reported in the PLOS Genetics paper, analysis of targeted and exome sequence data in a sample of ARIC and CHS participants is on-going (as part of a larger effort under the direction of Dr. Eric Boerwinkle). For more information about the study, including the full list of investigators and participating institutions and resulting publications, see www.cscc.unc.edu/carmri/. For information on securing access to data, refer to dbGaP (www.ncbi.nlm.nih.gov) and BIOPROJECT (www.ncbi.nlm.nih.gov/bioproject)

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000426-09
Application #
8556835
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2012
Total Cost
$12,175
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Xie, Jing; Ikram, M Kamran; Cotch, Mary Frances et al. (2017) Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Ophthalmol 135:586-593
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54
Tandon, Arti; Chen, Ching J; Penman, Alan et al. (2015) African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans. Invest Ophthalmol Vis Sci 56:3999-4005
Sabanayagam, Charumathi; Lye, Weng Kit; Klein, Ronald et al. (2015) Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia 58:2476-85
Ding, Jie; Wai, Khin Lay; McGeechan, Kevin et al. (2014) Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. J Hypertens 32:207-15
Holliday, Elizabeth G; Smith, Albert V; Cornes, Belinda K et al. (2013) Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One 8:e53830
Jensen, Richard A; Sim, Xueling; Li, Xiaohui et al. (2013) Genome-wide association study of retinopathy in individuals without diabetes. PLoS One 8:e54232
Sim, Xueling; Jensen, Richard A; Ikram, M Kamran et al. (2013) Genetic loci for retinal arteriolar microcirculation. PLoS One 8:e65804
Avery, Christy L; Kucharska-Newton, Anna; Monda, Keri L et al. (2012) Impact of long-term measures of glucose and blood pressure on the retinal microvasculature. Atherosclerosis 225:412-7
Sobrin, Lucia; Green, Todd; Sim, Xueling et al. (2011) Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci 52:7593-602

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