The primary objective of AREDS2 is to evaluate the effect of dietary xanthophylls (lutein/zeaxanthin) and/or omega-3 LCPUFAs (DHA and EPA) on progression to advanced AMD. This objective will be accomplished by collecting and assessing the data on approximately 4,000 AREDS2 participants aged 50 to 85 years (of which 65 participants are from the NIH center), who at the time of enrollment, have sufficiently clear lenses for quality fundus photographs and have either: 1) bilateral large drusen or 2) large drusen in one eye and advanced AMD (neovascular AMD or central geographic atrophy) in the fellow eye. The objectives of AREDS2 are to: 1. Study the effects of high supplemental doses of the dietary xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the development of advanced AMD. 2. Study the effects of these supplements on moderate vision loss (doubling of the visual angle or the loss of 15 or more letters on the ETDRS chart). 3. Study the effects of these supplements on cataract. 4. Study the effects of eliminating beta-carotene in the original AREDS formulation on the development and progression of AMD. 5. Study the effects of reducing zinc in the original AREDS formulation on the development and progression of AMD. 6. Validate the fundus photographic AMD scale developed from the Age-Related Eye Disease Study.

National Institute of Health (NIH)
National Eye Institute (NEI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
U.S. National Eye Institute
Zip Code
Veerappan, Malini; El-Hage-Sleiman, Abdul-Karim M; Tai, Vincent et al. (2016) Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration. Ophthalmology 123:2554-2570
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2015) Author reply: To PMID 24974817. Ophthalmology 122:e46-7
Chew, Emily Y; Clemons, Traci E; Agrón, Elvira et al. (2015) Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. JAMA 314:791-801
Chew, Emily Y (2015) There is level 1 evidence for intensive glycemic control for reducing the progression of diabetic retinopathy in persons with type 2 diabetes. Endocrine 49:1-3
Chen, Shida; Chew, Emily Y; Chan, Chi-Chao (2015) Pathology characteristics of ocular von Hippel-Lindau disease with neovascularization of the iris and cornea: a case report. J Med Case Rep 9:66
Flamendorf, Jason; Agrón, Elvira; Wong, Wai T et al. (2015) Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen. Ophthalmology 122:2053-62
Grassmann, Felix; Fleckenstein, Monika; Chew, Emily Y et al. (2015) Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration. PLoS One 10:e0126636
Glaser, Tanya S; Doss, Lauren E; Shih, Grace et al. (2015) The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37. Ophthalmology 122:1471-9
Ehler, Martin; Dobrosotskaya, Julia; Cunningham, Denise et al. (2015) Modeling Photo-Bleaching Kinetics to Create High Resolution Maps of Rod Rhodopsin in the Human Retina. PLoS One 10:e0131881
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2015) Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: to test or not to test? Ophthalmology 122:212-5

Showing the most recent 10 out of 59 publications