Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter each year. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to fertility and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment prospective time-to-pregnancy associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and fertility measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models. Secondary outcomes, including cardiovascular complications in labor/delivery, gestational diabetes, and birth defects are also addressed in relation to air quality and ambient temperature.
| Nobles, Carrie J; Schisterman, Enrique F; Ha, Sandie et al. (2018) Time-varying cycle average and daily variation in ambient air pollution and fecundability. Hum Reprod 33:166-176 |
| Nobles, Carrie J; Schisterman, Enrique F; Ha, Sandie et al. (2018) Ambient air pollution and semen quality. Environ Res 163:228-236 |
| Ha, Sandie; Liu, Danping; Zhu, Yeyi et al. (2018) Acute Associations Between Outdoor Temperature and Premature Rupture of Membranes. Epidemiology 29:175-182 |
| Ha, Sandie; Sundaram, Rajeshwari; Buck Louis, Germaine M et al. (2018) Ambient air pollution and the risk of pregnancy loss: a prospective cohort study. Fertil Steril 109:148-153 |
| Ha, Sandie; Nguyen, Kelly; Liu, Danping et al. (2017) Ambient temperature and risk of cardiovascular events at labor and delivery: A case-crossover study. Environ Res 159:622-628 |
| Ha, Sandie; Zhu, Yeyi; Liu, Danping et al. (2017) Ambient temperature and air quality in relation to small for gestational age and term low birthweight. Environ Res 155:394-400 |
| Ha, Sandie; Liu, Danping; Zhu, Yeyi et al. (2017) Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study. Environ Health Perspect 125:067011 |
| Mendola, Pauline; Ha, Sandie; Pollack, Anna Z et al. (2017) Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth. Int J Environ Res Public Health 14: |
| Mendola, Pauline; Sundaram, Rajeshwari; Louis, Germaine M Buck et al. (2017) Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility. Sci Total Environ 576:172-177 |
| Ha, Sandie; Männistö, Tuija; Liu, Danping et al. (2017) Air pollution and cardiovascular events at labor and delivery: a case-crossover analysis. Ann Epidemiol 27:377-383 |
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