Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter each year. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to fertility and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment prospective time-to-pregnancy associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and fertility measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models. Secondary outcomes, including cardiovascular complications in labor/delivery, gestational diabetes, and birth defects are also addressed in relation to air quality and ambient temperature.

Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2019
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Indirect Cost
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Nobles, Carrie J; Schisterman, Enrique F; Ha, Sandie et al. (2018) Time-varying cycle average and daily variation in ambient air pollution and fecundability. Hum Reprod 33:166-176
Nobles, Carrie J; Schisterman, Enrique F; Ha, Sandie et al. (2018) Ambient air pollution and semen quality. Environ Res 163:228-236
Ha, Sandie; Liu, Danping; Zhu, Yeyi et al. (2018) Acute Associations Between Outdoor Temperature and Premature Rupture of Membranes. Epidemiology 29:175-182
Ha, Sandie; Sundaram, Rajeshwari; Buck Louis, Germaine M et al. (2018) Ambient air pollution and the risk of pregnancy loss: a prospective cohort study. Fertil Steril 109:148-153
Ha, Sandie; Nguyen, Kelly; Liu, Danping et al. (2017) Ambient temperature and risk of cardiovascular events at labor and delivery: A case-crossover study. Environ Res 159:622-628
Ha, Sandie; Zhu, Yeyi; Liu, Danping et al. (2017) Ambient temperature and air quality in relation to small for gestational age and term low birthweight. Environ Res 155:394-400
Ha, Sandie; Liu, Danping; Zhu, Yeyi et al. (2017) Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study. Environ Health Perspect 125:067011
Mendola, Pauline; Ha, Sandie; Pollack, Anna Z et al. (2017) Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth. Int J Environ Res Public Health 14:
Mendola, Pauline; Sundaram, Rajeshwari; Louis, Germaine M Buck et al. (2017) Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility. Sci Total Environ 576:172-177
Ha, Sandie; Männistö, Tuija; Liu, Danping et al. (2017) Air pollution and cardiovascular events at labor and delivery: a case-crossover analysis. Ann Epidemiol 27:377-383

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