During the past year we performed first human cardiovascular MRI using a novel low-field and high-performance MRI system at 0.55T. The system preserves imaging with reduced SAR which allows MRI catheterization using conductive metallic cardiovascular guidewires. These allow using fundamental metallic catheter tools without dangerous heating. In collaboration with the laboratory of Adrienne Campbell-Washburn we are helping to characterize fundamental MR properties of tissues of interest at low field. We demonstrated the value of ferumoxytol (polysaccharide coated iron oxide nanoparticles) for indicator-dilution measurement of blood pool, validated against carbon monoxide in large mammals. This may prove a useful measure in patients with different hear failure phenotypes. We have investigated the value of low-field high-performance MRI to image iron susceptibility markers for guidewire tracking and navigation. We have explored the ability of real-time MRI at low field (0.55T) to visualize acute myocardial injury from radiofrequency ablation (RFA) and from chemoablation using ethanol or acetic acid. Preliminary data suggests acute injury from RFA is difficult to image in real-time across field strengths. By contrast, chemoablation lesions are readily visualized using real-time MRI. These findings will enable novel treatments for structural heart disease and rhythm disorders including MRI catheterization. We are working closely with industry, through a Collaborative Research and Development Agreement, system for safe patient hemodynamic monitoring and recording during interventional MRI experiments and during transfer between X-ray and MRI. We are working closely with industry to transfer our developments into commercial tools that can be used widely in medical care throughout the world.
| Campbell-Washburn, Adrienne E; Rogers, Toby; Stine, Annette M et al. (2018) Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience. J Cardiovasc Magn Reson 20:41 |
| Fischer, Peter; Faranesh, Anthony; Pohl, Thomas et al. (2018) An MR-Based Model for Cardio-Respiratory Motion Compensation of Overlays in X-Ray Fluoroscopy. IEEE Trans Med Imaging 37:47-60 |
| Kakareka, John W; Faranesh, Anthony Z; Pursley, Randall H et al. (2018) Physiological Recording in the MRI Environment (PRiME): MRI-Compatible Hemodynamic Recording System. IEEE J Transl Eng Health Med 6:4100112 |
| Campbell-Washburn, Adrienne E; Tavallaei, Mohammad A; Pop, Mihaela et al. (2017) Real-time MRI guidance of cardiac interventions. J Magn Reson Imaging 46:935-950 |
| Rogers, Toby; Ratnayaka, Kanishka; Khan, Jaffar M et al. (2017) CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients. J Cardiovasc Magn Reson 19:54 |
| Campbell-Washburn, Adrienne E; Xue, Hui; Lederman, Robert J et al. (2016) Real-time distortion correction of spiral and echo planar images using the gradient system impulse response function. Magn Reson Med 75:2278-85 |
| McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6 |
| Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70 |
| Rogers, Toby; Lederman, Robert J (2016) Exercise Magnetic Resonance Imaging Is a Gas. Circ Cardiovasc Imaging 9: |
| Mazal, Jonathan R; Rogers, Toby; Schenke, William H et al. (2016) Interventional-Cardiovascular MR: Role of the Interventional MR Technologist. Radiol Technol 87:261-70 |
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