We are continuing development of this novel catheter technique, which establishes circumferential tension around the mitral valve annulus by exploiting both natural (coronary venous) and un-natural (intramyocardial septal) trajectories. We have established proof-of-principal in a porcine model of ischemic cardiomyopathy that cerclage annuloplasty reduces secondary (""""""""functional"""""""") mitral valve regurgitation. We have developed new catheter designs to simplify the procedure. We are attempting to reduce the demands on image guidance for the procedure. We are assembling resources toward Investigational Device Exemption clinical protocols.

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National Heart, Lung, and Blood Institute
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Khan, Jaffar M; Rogers, Toby; Babaliaros, Vasilis C et al. (2018) Predicting Left Ventricular Outflow Tract Obstruction Despite Anterior Mitral Leaflet Resection: The ""Skirt NeoLVOT"". JACC Cardiovasc Imaging 11:1356-1359
Khan, Jaffar M; Dvir, Danny; Greenbaum, Adam B et al. (2018) Transcatheter Laceration of Aortic Leaflets to Prevent Coronary Obstruction During Transcatheter Aortic Valve Replacement: Concept to First-in-Human. JACC Cardiovasc Interv 11:677-689
Khan, Jaffar M; Rogers, Toby; Eng, Marvin H et al. (2018) Guidewire electrosurgery-assisted trans-septal puncture. Catheter Cardiovasc Interv 91:1164-1170
Babaliaros, Vasilis; Greenbaum, Adam B; Kamioka, Norihiko et al. (2018) Bedside Modification of Delivery System for Transcatheter Transseptal Mitral Replacement With POULEZ System and SAPIEN-3 Valve. JACC Cardiovasc Interv 11:1207-1209
Khan, Jaffar M; Rogers, Toby; Schenke, William H et al. (2018) Transcatheter pledget-assisted suture tricuspid annuloplasty (PASTA) to create a double-orifice valve. Catheter Cardiovasc Interv 92:E175-E184
Khan, Jaffar M; Lederman, Robert J; Sanon, Saurabh et al. (2018) Transcatheter Mitral Valve Replacement After Transcatheter Electrosurgical Laceration of Alfieri STItCh (ELASTIC): First-in-Human Report. JACC Cardiovasc Interv 11:808-811
Rogers, Toby; Lederman, Robert J (2018) Percutaneous transaxillary access for TAVR: Another opportunity to stay out of the chest. Catheter Cardiovasc Interv 91:157-158
Kasel, A Markus; Rumpf, Moritz; Frangieh, Antonio H et al. (2018) International LAMPOON: first European experience with laceration of the anterior mitral valve leaflet prior to transseptal transcatheter mitral valve implantation. EuroIntervention 14:746-749
Khan, Jaffar M; Lederman, Robert J (2018) Transcatheter electrosurgery in bipolar or monopolar modes. Catheter Cardiovasc Interv 91:1052-1053
Greenbaum, Adam B; Condado, Jose F; Eng, Marvin et al. (2018) Long or redundant leaflet complicating transcatheter mitral valve replacement: Case vignettes that advocate for removal or reduction of the anterior mitral leaflet. Catheter Cardiovasc Interv 92:627-632

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