The mission of the SAXS Core facility is to provide support to research projects from CCR principle investigators (PIs), NIH intramural PIs and extramural academic research groups/laboratories. The support includes providing routine access to the APS PUP SAXS/WAXS beamline and in-house SAXS instrument, and expertise in experimental design, data collection, processing, analysis and interpretation. Our main focus is to determine structure of biomacromolecules and their complexes in solution. The research field includes but not limited to structural studies of nucleic acids, proteins, protein assemblies, virus particles, lipid membranes, protein/DNA and protein/RNA complexes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICBC011535-05
Application #
9780255
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Liu, Yu; Holmstrom, Erik; Zhang, Jinwei et al. (2015) Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature 522:368-72
Ithychanda, Sujay Subbayya; Fang, Xianyang; Mohan, Maradumane L et al. (2015) A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A. J Biol Chem 290:8527-38
Lemak, Alexander; Wu, Bin; Yee, Adelinda et al. (2014) Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data. Structure 22:1862-1874
Chang, Feng-Ming James; Coyne, H Jerome; Cubillas, Ciro et al. (2014) Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR). J Biol Chem 289:19204-17