The Imaging Probe Development Center (IPDC) produces known and novel imaging probes for the NIH intramural research community. The IPDC was one of the components of the molecular imaging aspect of the NIH Roadmap initiative. The IPDC laboratories began full operations in 2007, and provided increased PET labeling capabilities in 2014. The IPDC is now part of the NIH Intramural Program. The group has produced an exceptional number of probe compositions between 2007 and 2019. The probes extend across all imaging modalities including MRI, PET, SPECT, and Optical imaging. IPDC produces new probes and repeats and scales-up current probe syntheses in order to supply requests for probes from multiple investigators. The group has prepared dendrimers, nanoparticles, labeled antibodies, small molecules, peptides and radiolabeled compounds. The work at IPDC has been reported to the scientific community in posters at scientific meetings and publications in peer reviewed journals. A website, linked to the National Heart, Lung, and Blood Institutes website (www.nhlbi.nih.gov/research/intramural/researchers/programs/imaging-probe-development-center) is available to view publications, project requests and a database which showcases the diverse probes our staff have developed since the inception of the Imaging Probe Development Center. From there, other interested NIH intramural scientists may request probes from IPDC and study the synthetic methods used to prepare the probes, should they wish to attempt certain probe syntheses themselves. In 2014 the PET chemists of IPDC moved into a new lab in Building 10 of the NIH campus, with three hotcells and increased capacity for producing 18F PET ligands. We have also produced 89Zr labeled antibodies. At this point, the IPDC is fully operational and will see a further strengthening of its capabilities, knowledge and its probe production potential. Recently, IPDC has prepared PROTACS compounds and performed feature identification for metabolomics projects. The IPDC will continue to be fully inclusive as a resource for all NIH Institutes and Centers. We will continue to look to improve translation of imaging probes into the realms of clinical development.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICHL005090-14
Application #
10003803
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2019
Total Cost
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Zhang, Xiang; Dunlow, Ryan; Blackman, Burchelle N et al. (2018) Optimization of 18 F-syntheses using 19 F-reagents at tracer-level concentrations and liquid chromatography/tandem mass spectrometry analysis: Improved synthesis of [18 F]MDL100907. J Labelled Comp Radiopharm 61:427-437
Basuli, Falguni; Zhang, Xiang; Williams, Mark R et al. (2018) One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging. Nucl Med Biol 62-63:63-70
Brugarolas, Pedro; Sánchez-Rodríguez, Jorge E; Tsai, Hsiu-Ming et al. (2018) Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep 8:607
Kuszpit, Kyle; Hollidge, Bradley S; Zeng, Xiankun et al. (2018) [18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice. Mol Imaging Biol 20:275-283
Basuli, Falguni; Zhang, Xiang; Brugarolas, Pedro et al. (2018) An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement. J Labelled Comp Radiopharm 61:112-117
Brown, Zachary J; Fu, Qiong; Ma, Chi et al. (2018) Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. Cell Death Dis 9:620
Basuli, Falguni; Zhang, Xiang; Jagoda, Elaine M et al. (2018) Rapid synthesis of maleimide functionalized fluorine-18 labeled prosthetic group using ""radio-fluorination on the Sep-Pak"" method. J Labelled Comp Radiopharm 61:599-605
Zhang, Xiang; Basuli, Falguni; Shi, Zhen-Dan et al. (2016) Automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module. Appl Radiat Isot 112:110-4
Strickland, Madeleine; Schwieters, Charles D; Göbl, Christoph et al. (2016) Characterizing the magnetic susceptibility tensor of lanthanide-containing polymethylated-DOTA complexes. J Biomol NMR 66:125-139
Basuli, Falguni; Zhang, Xiang; Jagoda, Elaine M et al. (2016) Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18. Nucl Med Biol 43:770-772

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