Abstract

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus 08-AR-0218 Rilonacept to Treat Familial Mediterranean Fever 09-AR-0066 Canakinumab to Treat Neonatal Onset Multisystem Inflammatory Disease

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAR041180-03
Application #
8175436
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2010
Total Cost
$6,138,792
Indirect Cost

  Institution

Name
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

De Lorenzo, Rebecca; Pinal-Fernandez, Iago; Huang, Wilson et al. (2018) Muscular and extramuscular clinical features of patients with anti-PM/Scl autoantibodies. Neurology 90:e2068-e2076
Jha, Smita; Fratzl-Zelman, Nadja; Roschger, Paul et al. (2018) Distinct clinical and pathological features of melorheostosis associated with somatic MAP2K1 mutations. J Bone Miner Res :
Sanchez, Gina A Montealegre; Reinhardt, Adam; Ramsey, Suzanne et al. (2018) JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. J Clin Invest 128:3041-3052
Pinal-Fernandez, Iago; Casal-Dominguez, Maria; Mammen, Andrew L (2018) Immune-Mediated Necrotizing Myopathy. Curr Rheumatol Rep 20:21
Sikora, Keith A; Bennett, Joshua R; Vyncke, Laurens et al. (2018) Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis. J Allergy Clin Immunol 141:1943-1947.e9
Ward, Michael M; Hu, Jinxiang; Guthrie, Lori C et al. (2018) Testing the construct validity of a health transition question using vignette-guided patient ratings of health. Health Qual Life Outcomes 16:2
Brunham, Liam R; Baker, Steven; Mammen, Andrew et al. (2018) Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. Cardiovasc Res 114:1073-1081
Barrera-Vargas, Ana; Gómez-Martín, Diana; Carmona-Rivera, Carmelo et al. (2018) Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus. Ann Rheum Dis 77:944-950
Mistry, Pragnesh; Carmona-Rivera, Carmelo; Ombrello, Amanda K et al. (2018) Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome. Ann Rheum Dis :
Szymanski, Ann Marie; Ombrello, Michael J (2018) Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1. Int Immunol 30:205-213

Showing the most recent 10 out of 217 publications