Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR002243-02S1
Application #
9654067
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2018-03-26
Budget End
2019-02-28
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Holzmacher, Jeremy L; Reynolds, Cassandra; Patel, Mayur et al. (2018) Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy. Brain Inj 32:325-330
Hellwege, Jacklyn N; Russell, Shirley B; Williams, Scott M et al. (2018) Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann Hum Genet 82:206-215
Yiadom, Maame Yaa A B; Domenico, Henry; Byrne, Daniel et al. (2018) Randomised controlled pragmatic clinical trial evaluating the effectiveness of a discharge follow-up phone call on 30-day hospital readmissions: balancing pragmatic and explanatory design considerations. BMJ Open 8:e019600
Lyu, Ilwoo; Kang, Hakmook; Woodward, Neil D et al. (2018) Sulcal Depth-based Cortical Shape Analysis in Normal Healthy Control and Schizophrenia Groups. Proc SPIE Int Soc Opt Eng 10574:
Rogers, Baxter P; Blaber, Justin; Newton, Allen T et al. (2018) Phantom-based field maps for gradient nonlinearity correction in diffusion imaging. Proc SPIE Int Soc Opt Eng 10573:
Bastas, Gerasimos; Fleck, Joshua J; Peters, Richard A et al. (2018) IMU-based gait analysis in lower limb prosthesis users: Comparison of step demarcation algorithms. Gait Posture 64:30-37
Huo, Yuankai; Liu, Jiaqi; Xu, Zhoubing et al. (2018) Robust Multicontrast MRI Spleen Segmentation for Splenomegaly Using Multi-Atlas Segmentation. IEEE Trans Biomed Eng 65:336-343
Dang, Linh C; Samanez-Larkin, Gregory R; Castrellon, Jaime J et al. (2018) Individual differences in dopamine D2 receptor availability correlate with reward valuation. Cogn Affect Behav Neurosci 18:739-747
O'Connor, Amy M; Smith, Andrew H; Crum, Kim et al. (2018) Analysis of clinical and candidate genetic risk factors for postoperative atrial tachycardia after congenital heart surgery in infants. Am Heart J 202:1-4
Dahir, Kathryn M; Tilden, Daniel R; Warner, Jeremy L et al. (2018) Rare Variants in the Gene ALPL That Cause Hypophosphatasia Are Strongly Associated With Ovarian and Uterine Disorders. J Clin Endocrinol Metab 103:2234-2243

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