Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR002243-04
Application #
9878150
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2020-03-01
Budget End
2021-02-28
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Rebeiro, Peter F; McPherson, Tristan D; Goggins, Kathryn M et al. (2018) Health Literacy and Demographic Disparities in HIV Care Continuum Outcomes. AIDS Behav 22:2604-2614
Short, Sarah P; Pilat, Jennifer M; Williams, Christopher S (2018) Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease. Free Radic Biol Med 127:26-35
Bellomy, Melissa L; Freundlich, Robert E (2018) Hyperglycemia and Elevated Lactate in Trauma: Where Do We Go From Here? Anesth Analg 126:748-749
Wilson, Jessica R; Brown, Nancy J; Nian, Hui et al. (2018) Dipeptidyl Peptidase-4 Inhibition Potentiates Stimulated Growth Hormone Secretion and Vasodilation in Women. J Am Heart Assoc 7:
Goldstein, Jeffery A; Bastarache, Lisa A; Denny, Joshua C et al. (2018) Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications. Pharmacol Res 130:44-51
Humble, Stephen S; Wilson, Laura D; Wang, Li et al. (2018) Prognosis of diffuse axonal injury with traumatic brain injury. J Trauma Acute Care Surg 85:155-159
Cambronero, Francis E; Liu, Dandan; Neal, Jacquelyn E et al. (2018) APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiol Aging 67:120-127
Stone Jr, Cosby; Qiu, Yunping; Kurland, Irwin J et al. (2018) Effect of Maternal Smoking on Plasma and Urinary Measures of Vitamin E Isoforms in the First Month after Extreme Preterm Birth. J Pediatr 197:280-285.e3
York, Michelle K; Gupta, Deepak K; Reynolds, Cassandra F et al. (2018) B-Type Natriuretic Peptide Levels and Mortality in Patients With and Without Heart Failure. J Am Coll Cardiol 71:2079-2088
Zengin-Bolatkale, Hatun; Conture, Edward G; Walden, Tedra A et al. (2018) Sympathetic arousal as a marker of chronicity in childhood stuttering. Dev Neuropsychol 43:135-151

Showing the most recent 10 out of 162 publications