Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR002243-05
Application #
10114340
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
5
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Knowlton, Jonathan J; Fernández de Castro, Isabel; Ashbrook, Alison W et al. (2018) The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat Microbiol 3:481-493
Dare, Ryan K; Tewell, Chad; Harris, Bryan et al. (2018) Effect of Statin Coadministration on the Risk of Daptomycin-Associated Myopathy. Clin Infect Dis 67:1356-1363
Riddler, Sharon A; Zheng, Lu; Durand, Christine M et al. (2018) Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART. Open Forum Infect Dis 5:ofy242
Garber, J; Weersing, V R; Hollon, S D et al. (2018) Prevention of Depression in At-Risk Adolescents: Moderators of Long-term Response. Prev Sci 19:6-15
Boyer, Alaina P; Fair, Alecia M; Joosten, Yvonne A et al. (2018) A Multilevel Approach to Stakeholder Engagement in the Formulation of a Clinical Data Research Network. Med Care 56 Suppl 10 Sup:S22-S26
Perez, Katia M; Lee, Evon B; Kahanda, Sachini et al. (2018) Cognitive and behavioral phenotype of children with pseudohypoparathyroidism type 1A. Am J Med Genet A 176:283-289
Hemnes, Anna R; Opotowsky, Alexander R; Assad, Tufik R et al. (2018) Features Associated With Discordance Between Pulmonary Arterial Wedge Pressure and Left Ventricular End Diastolic Pressure in Clinical Practice: Implications for Pulmonary Hypertension Classification. Chest 154:1099-1107
Erdemir, Aysu; Walden, Tedra A; Jefferson, Caswell M et al. (2018) The effect of emotion on articulation rate in persistence and recovery of childhood stuttering. J Fluency Disord 56:1-17
Turi, Kedir N; Shankar, Jyoti; Anderson, Larry J et al. (2018) Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze. Am J Respir Crit Care Med 198:1064-1073
Jerome, Rebecca N; Pulley, Jill M; Roden, Dan M et al. (2018) Reply to Ward and Colleagues' Comment on ""Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"". Drug Saf 41:1101

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