Obesity has become a global health concern because it is linked to such conditions as cardiovascular disease, diabetes, respiratory illness, and others. The work described in this proposal will """"""""contribute to our understanding of the mechanisms underlying obesity and insulin resistance by examining how the pro-obesity hormone ghrelin triggers overeating, weight gain, and hyperglycemia.""""""""
|Frazao, Renata; Dungan Lemko, Heather M; da Silva, Regina P et al. (2014) Estradiol modulates Kiss1 neuronal response to ghrelin. Am J Physiol Endocrinol Metab 306:E606-14|
|Dungan Lemko, Heather M; Elias, Carol F (2012) Kiss of the mutant mouse: how genetically altered mice advanced our understanding of kisspeptin's role in reproductive physiology. Endocrinology 153:5119-29|