Abstract

The candidate, Anthony J. Donate Ph.D., is a cardiovascular physiologist in the Department of Integrative Physiology at the University of Colorado at Boulder. Dr. Donato's research focuses on the mechanisms mediating vascular aging in humans and how habitual aerobic exercise can preserve and restore vascular health with aging.
The aim of the research project is to establish the efficacy of a 12-week aerobic exercise intervention for restoring vascular endothelial function in middle-aged and older men and women by inducing reductions in oxidative stress and increases in nitric oxide bioavailability. The proposed research will use an """"""""integrative"""""""" (system to gene) approach to identify the cellular and molecular mechanisms by which habitual exercise restores endothelial function in this group, including measurements of vascular endothelial expression of proteins influencing oxidative stress, inflammation and nitric oxide production. The expected results should provide clinically important information regarding the integrative physiological mechanisms by which habitual aerobic exercise improves vascular endothelial function in middle-aged and older adults.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
7K01AG029337-05
Application #
8202644
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Rossi, Winifred K
Project Start
2007-09-15
Project End
2012-06-30
Budget Start
2011-03-15
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$122,499
Indirect Cost

  Institution

Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Frech, Tracy; Walker, Ashley E; Barrett-O'Keefe, Zachary et al. (2015) Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction. Clin Rheumatol 34:905-13
Donato, Anthony J; Morgan, R Garrett; Walker, Ashley E et al. (2015) Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol 89:122-35
Gano, Lindsey B; Donato, Anthony J; Pasha, Hamza M et al. (2014) The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol 307:H1754-63
Venturelli, Massimo; Morgan, Garrett R; Donato, Anthony J et al. (2014) Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. Clin Sci (Lond) 127:415-21
Walker, Ashley E; Henson, Grant D; Reihl, Kelly D et al. (2014) Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries. Age (Dordr) 36:559-69
Morgan, R Garrett; Ives, Stephen J; Walker, Ashley E et al. (2014) Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens 32:1293-9
Morgan, Richard G; Ives, Stephen J; Lesniewski, Lisa A et al. (2013) Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries. Am J Physiol Heart Circ Physiol 305:H251-8
Donato, Anthony J; Walker, Ashley E; Magerko, Katherine A et al. (2013) Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell 12:772-83
Rippe, Catarina; Blimline, Mark; Magerko, Katherine A et al. (2012) MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol 47:45-51
Ives, S J; Andtbacka, R H I; Park, S-Y et al. (2012) Human skeletal muscle feed arteries: evidence of regulatory potential. Acta Physiol (Oxf) 206:135-41

Showing the most recent 10 out of 33 publications