The purpose of this proposed Senior Scientist Award (K05) from the National Institute on Drug Abuse is to provide stability of support for Professor James C. Anthony of the Johns Hopkins University, Bloomberg School of Public Health, in relation to his program of continuing research, research training, mentoring, and science education on the topics of drug dependence epidemiology and enviromics. The research plan and career development activities are organized in relation to five main rubrics of epidemiology and associated research questions: (1) Within the population, how many people are becoming affected by clinically significant syndromes of drug dependence? How many cases have accumulated? (2) Within the population, where are we more (or less) likely to find drug dependence cases, in relation to characteristics of person, place, and time? (3) What accounts for some people becoming drug dependent while others are spared? (4) How do linked sequences of events and processes lead toward the transition from being a non-case to becoming a case of drug dependence, and the hazardous consequences of becoming or being a case? and (5) What can we do to prevent, delay, or reduce the risk of becoming a case of drug dependence, to reduce the duration, or to ameliorate the associated suffering? Whereas the 'genome' refers to the total ensemble of genetic material for a form of life, the 'envirome' is the total ensemble of environmental processes and circumstances required for life form viability and successful adaptation. In complement with genomics and proteomics, drug dependence enviromics is a deliberate search for specific environmental processes and circumstances that promote health by reducing the risk, prevalence, and problems of drug dependence. In drug dependence enviromics, the main objects of study are neither the gene nor the environment, but rather the gene-environment interactions that give rise to drug dependence, prevent or sustain it, interrupt its natural history, and reduce the global burden of drug dependence and associated disabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA015799-03
Application #
6806531
Study Section
Special Emphasis Panel (ZDA1-MXS-M (20))
Program Officer
Etz, Kathleen
Project Start
2003-09-30
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$145,203
Indirect Cost
Name
Michigan State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Cheng, Hui G; Anthony, James C (2018) Male-female differences in the onset of heavy drinking episode soon after first full drink in contemporary United States: From early adolescence to young adulthood. Drug Alcohol Depend 190:159-165
Alonso, Jordi; Liu, Zhaorui; Evans-Lacko, Sara et al. (2018) Treatment gap for anxiety disorders is global: Results of the World Mental Health Surveys in 21 countries. Depress Anxiety 35:195-208
Frounfelker, Rochelle; Gilman, Stephen E; Betancourt, Theresa S et al. (2018) Civilians in World War II and DSM-IV mental disorders: results from the World Mental Health Survey Initiative. Soc Psychiatry Psychiatr Epidemiol 53:207-219
Bares, Cristina B; Dick, Danielle M; Kendler, Kenneth S (2018) Nicotine dependence, internalizing symptoms, mood variability and daily tobacco use among young adult smokers. Addict Behav 83:87-94
Parker, Maria A; Lopez-Quintero, Catalina; Anthony, James C (2018) Young, American Indian or Alaskan Native, and born in the USA: at excess risk of starting extra-medical prescription pain reliever use? PeerJ 6:e5713
Kessler, R C; Aguilar-Gaxiola, S; Alonso, J et al. (2018) The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. Mol Psychiatry 23:1-8
Parker, Maria A; Anthony, James C (2018) Underage drinking, alcohol dependence, and young people starting to use prescription pain relievers extra-medically: A zero-inflated Poisson regression model. Exp Clin Psychopharmacol :
Salas-Wright, Christopher P; Vaughn, Michael G; Goings, Trenette C et al. (2018) Immigrants and mental disorders in the united states: New evidence on the healthy migrant hypothesis. Psychiatry Res 267:438-445
de Jonge, Peter; Wardenaar, Klaas J; Lim, Carmen C W et al. (2018) The cross-national structure of mental disorders: results from the World Mental Health Surveys. Psychol Med 48:2073-2084
Cheng, Hui G; Lopez-Quintero, Catalina; Anthony, James C (2018) Age of onset or age at assessment-that is the question: Estimating newly incident alcohol drinking and rapid transition to heavy drinking in the United States, 2002-2014. Int J Methods Psychiatr Res 27:

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