The proposed K05 Senior Scientist award renewal will give Professor James C. (Jim) Anthony of Michigan State University (MSU) protected time for a minimum of 75% FTE devoted to NIDA's research mission in relation to three elements of activity. First, continuation of his strong mentorship of early career stage (ECS) and junior investigators at MSU and at other institutions, as well as continued direction of MSU's Drug Dependence Epidemiology Training Program during its anticipated concurrent renewal period. Second, continuation of his 3 current NIDA R01-supported epidemiology/prevention research projects as well as development of new projects of an exploratory/development character, designed to address a serious challenge of study non- participation and sample attrition in recent epidemiology/prevention field studies. Third, continuation of his own career development in relation to topics of central and mutual interest to the ECS and other mentees he will serve (e.g., epidemiology/prevention research in 'drug dependence enviromics') and responsible research training. Here, whereas the 'genome'refers to the total ensemble of genetic material for each life form, the 'envirome'is the total ensemble of environmental processes and circumstances required for life form viability and successful adaptation. In complement with genomics and proteomics, drug dependence enviromics is a deliberate search for specific environmental processes and circumstances that promote health by reducing the risk, prevalence, and problems of drug dependence. In drug dependence enviromics, the main objects of study are neither the gene nor the environment, but rather the gene-environment interactions that give rise to drug dependence, prevent or sustain it, interrupt its natural history, and reduce the global burden of drug dependence and associated disabilities. The long-term goal is definitive evidence on practical population-level public health approaches to the prevention and control of drug dependence processes, from early process steps (e.g., 1st chance to try a drug;1st onset of use) to later steps (e.g., coalescence of drug dependence syndrome, secondary consequences, death by drug overdose or other misadventure), with due attention to cessation of drug use as well.

Public Health Relevance

In drug dependence enviromics research, we seek to discover environmental conditions and processes that drive practical population-level public health prevention and control techniques. For success in public health work, results must be reduced population-level prevalence of drug dependence in complement with clinical work focused on individually tailored plans for patient care (e.g., drug dependence treatment).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA015799-09
Application #
8450928
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Schulden, Jeffrey D
Project Start
2003-09-30
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
9
Fiscal Year
2013
Total Cost
$130,028
Indirect Cost
$9,632
Name
Michigan State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Scott, K M; Koenen, K C; King, A et al. (2018) Post-traumatic stress disorder associated with sexual assault among women in the WHO World Mental Health Surveys. Psychol Med 48:155-167
Mortier, Philippe; Auerbach, Randy P; Alonso, Jordi et al. (2018) Suicidal thoughts and behaviors among college students and same-aged peers: results from the World Health Organization World Mental Health Surveys. Soc Psychiatry Psychiatr Epidemiol 53:279-288
Cheng, Hui G; Anthony, James C (2018) Female-male differences in alcohol dependence levels: Evidence on newly incident adolescent and young-adult drinkers in the United States, 2002-2014. Int J Methods Psychiatr Res 27:e1717
Negi, Nalini Junko; Maskell, Erin; Goodman, Marci et al. (2018) Providing social services in a new immigrant settlement city: A qualitative inquiry. Am J Orthopsychiatry 88:16-25
Alonso, Jordi; Mortier, Philippe; Auerbach, Randy P et al. (2018) Severe role impairment associated with mental disorders: Results of the WHO World Mental Health Surveys International College Student Project. Depress Anxiety 35:802-814
Negi, Nalini Junko; Prickett, Julia Clark; Overdorff, Adrianna Marie et al. (2018) Return-Migration to Mexico and the Gendered Transnational Migration Process. Psychol Men Masc 19:385-391
Peralta, Robert L; L Mulhollem, Marcella; Blue, Courtney et al. (2018) The Association between Heavy Episodic Drinking and Gender Orientation among U.S. College Students: The Significance of Masculinity. Subst Use Misuse 53:910-920
Parker, Maria A; Anthony, James C (2018) Population-level predictions from cannabis risk perceptions to active cannabis use prevalence in the United States, 1991-2014. Addict Behav 82:101-104
Bruffaerts, Ronny; Mortier, Philippe; Kiekens, Glenn et al. (2018) Mental health problems in college freshmen: Prevalence and academic functioning. J Affect Disord 225:97-103
Degenhardt, Louisa; Saha, Sukanta; Lim, Carmen C W et al. (2018) The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. Addiction 113:924-934

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