The proposed K05 Senior Scientist award renewal will give Professor James C. (Jim) Anthony of Michigan State University (MSU) protected time for a minimum of 75% FTE devoted to NIDA's research mission in relation to three elements of activity. First, continuation of his strong mentorship of early career stage (ECS) and junior investigators at MSU and at other institutions, as well as continued direction of MSU's Drug Dependence Epidemiology Training Program during its anticipated concurrent renewal period. Second, continuation of his 3 current NIDA R01-supported epidemiology/prevention research projects as well as development of new projects of an exploratory/development character, designed to address a serious challenge of study non- participation and sample attrition in recent epidemiology/prevention field studies. Third, continuation of his own career development in relation to topics of central and mutual interest to the ECS and other mentees he will serve (e.g., epidemiology/prevention research in 'drug dependence enviromics') and responsible research training. Here, whereas the 'genome'refers to the total ensemble of genetic material for each life form, the 'envirome'is the total ensemble of environmental processes and circumstances required for life form viability and successful adaptation. In complement with genomics and proteomics, drug dependence enviromics is a deliberate search for specific environmental processes and circumstances that promote health by reducing the risk, prevalence, and problems of drug dependence. In drug dependence enviromics, the main objects of study are neither the gene nor the environment, but rather the gene-environment interactions that give rise to drug dependence, prevent or sustain it, interrupt its natural history, and reduce the global burden of drug dependence and associated disabilities. The long-term goal is definitive evidence on practical population-level public health approaches to the prevention and control of drug dependence processes, from early process steps (e.g., 1st chance to try a drug;1st onset of use) to later steps (e.g., coalescence of drug dependence syndrome, secondary consequences, death by drug overdose or other misadventure), with due attention to cessation of drug use as well.
In drug dependence enviromics research, we seek to discover environmental conditions and processes that drive practical population-level public health prevention and control techniques. For success in public health work, results must be reduced population-level prevalence of drug dependence in complement with clinical work focused on individually tailored plans for patient care (e.g., drug dependence treatment).
|Cheng, Hui G; Anthony, James C (2018) Female-male differences in alcohol dependence levels: Evidence on newly incident adolescent and young-adult drinkers in the United States, 2002-2014. Int J Methods Psychiatr Res 27:e1717|
|Negi, Nalini Junko; Maskell, Erin; Goodman, Marci et al. (2018) Providing social services in a new immigrant settlement city: A qualitative inquiry. Am J Orthopsychiatry 88:16-25|
|Alonso, Jordi; Mortier, Philippe; Auerbach, Randy P et al. (2018) Severe role impairment associated with mental disorders: Results of the WHO World Mental Health Surveys International College Student Project. Depress Anxiety 35:802-814|
|Negi, Nalini Junko; Prickett, Julia Clark; Overdorff, Adrianna Marie et al. (2018) Return-Migration to Mexico and the Gendered Transnational Migration Process. Psychol Men Masc 19:385-391|
|Peralta, Robert L; L Mulhollem, Marcella; Blue, Courtney et al. (2018) The Association between Heavy Episodic Drinking and Gender Orientation among U.S. College Students: The Significance of Masculinity. Subst Use Misuse 53:910-920|
|Parker, Maria A; Anthony, James C (2018) Population-level predictions from cannabis risk perceptions to active cannabis use prevalence in the United States, 1991-2014. Addict Behav 82:101-104|
|Bruffaerts, Ronny; Mortier, Philippe; Kiekens, Glenn et al. (2018) Mental health problems in college freshmen: Prevalence and academic functioning. J Affect Disord 225:97-103|
|Degenhardt, Louisa; Saha, Sukanta; Lim, Carmen C W et al. (2018) The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. Addiction 113:924-934|
|Holzer, Katherine J; Oh, Sehun; Salas-Wright, Christopher P et al. (2018) Gender differences in the trends and correlates of major depressive episodes among juvenile offenders in the United States. Compr Psychiatry 80:72-80|
|Cheng, Hui G; Anthony, James C (2018) Male-female differences in the onset of heavy drinking episode soon after first full drink in contemporary United States: From early adolescence to young adulthood. Drug Alcohol Depend 190:159-165|
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