Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002433-02
Application #
2134380
Study Section
Special Emphasis Panel (SRC)
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Huang, S C; Lavine, J E; Boland, P S et al. (2001) Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr 138:629-35
Yashiro, M; Carethers, J M; Laghi, L et al. (2001) Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res 61:2676-83
Chauhan, D P; Yang, Q; Carethers, J M et al. (2000) Antisense inhibition of hMLH1 is not sufficient for loss of DNA mismatch repair function in the HCT116+chromosome 3 cell line. Clin Cancer Res 6:3827-31
Carethers, J M; Pham, T T (2000) Mutations of transforming growth factor beta 1 type II receptor, BAX, and insulin-like growth factor II receptor genes in microsatellite unstable cell lines. In Vivo 14:13-20
Carethers, J M (1999) Racial and ethnic factors in the genetic pathogenesis of colorectal cancer. J Assoc Acad Minor Phys 10:59-67
Carethers, J M; Chauhan, D P; Fink, D et al. (1999) Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology 117:123-31
Carethers, J M; Hawn, M T; Greenson, J K et al. (1998) Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 114:1188-95
Boland, C R; Sato, J; Saito, K et al. (1998) Genetic instability and chromosomal aberrations in colorectal cancer: a review of the current models. Cancer Detect Prev 22:377-82
Carethers, J M; Furnari, F B; Zigman, A F et al. (1998) Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res 58:2724-6
Zigman, A F; Lavine, J E; Jones, M C et al. (1997) Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23. Gastroenterology 113:1433-7

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