This is an application for a K24 Mid-Career Investigator Award in Patient Oriented Research for Scott H. Kollins, Ph.D. Dr. Kollins is an established expert in the areas of Attention Deficit Hyperactivity Disorder (ADHD) and stimulant psychopharmacology. He has been involved with and published a number of studies on clinical trials with ADHD patients and has conducted seminal work on the abuse potential of stimulant drugs as they pertain to the treatment of ADHD. More recently, Dr. Kollins'work has begun to identify important mechanisms that underlie the relationship between ADHD and nicotine dependence. The purpose of this K24 application is three-fold: 1) to extend Dr. Kollins'established record of patient-oriented research with individuals with ADHD;2) to explore the genetic and neuropsychopharmacological basis of nicotine dependence in these individuals;and 3) to allow Dr. Kollins to develop more formal mentoring arrangements with post-doctoral trainees and junior faculty in the areas of ADHD and nicotine dependence. The career development plan for this application will extend the applicant's knowledge and skills in two key areas: 1) molecular genetics;and 2) functional brain neuroimaging. Dr. Kollins will leverage existing collaborative relationships at Duke University Medical Center to accomplish these aims. The research plan for this application will build on existing and pending projects to further understand the association between ADHD and nicotine dependence. These studies include: 1) an existing human laboratory study of the abuse liability of methylphenidate in adults with and without ADHD (R01DA017196);2) an existing candidate gene study of persistent ADHD (R01NS049067);and 3) an existing laboratory study of the effects of nicotine withdrawal in ADHD and non-ADHD smokers (R21DA020806). New research will also be conducted to study the effects of stimulant drugs on smoking behavior in patients with ADHD and to explore the genetic and functional brain correlates of these effects. This research is of considerable public health significance. ADHD affects millions of individuals in the US and patients with ADHD smoke cigarettes at a significantly higher rate than the general population. Given that smoking is the single largest preventable cause of death and disease, understanding more about the relationship between ADHD and smoking/nicotine dependence therefore has the potential to prevent or treat a major public health and mental health problem.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lin, Yu
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Medicine
United States
Zip Code
Mitchell, John T; Weisner, Thomas S; Jensen, Peter S et al. (2018) How Substance Users With ADHD Perceive the Relationship Between Substance Use and Emotional Functioning. J Atten Disord 22:49S-60S
Gao, Lu; Liu, Xiaochen; Millstein, Joshua et al. (2018) Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. Clin Epigenetics 10:98
Schechter, Julia C; Fuemmeler, Bernard F; Hoyo, Cathrine et al. (2018) Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States. Int J Environ Res Public Health 15:
Sweitzer, Maggie M; Kollins, Scott H; Kozink, Rachel V et al. (2018) ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge. Neuropsychopharmacology 43:851-858
Mitchell, John T; Howard, Andrea L; Belendiuk, Katherine A et al. (2018) Cigarette Smoking Progression among Young Adults Diagnosed with ADHD in Childhood: A 16-year Longitudinal Study of Children with and without ADHD. Nicotine Tob Res :
Mitchell, John T; McIntyre, Elizabeth M; English, Joseph S et al. (2017) A Pilot Trial of Mindfulness Meditation Training for ADHD in Adulthood: Impact on Core Symptoms, Executive Functioning, and Emotion Dysregulation. J Atten Disord 21:1105-1120
Schechter, Julia C; Kollins, Scott H (2017) Prenatal Smoke Exposure and ADHD: Advancing the Field. Pediatrics 139:
Schoenfelder, Erin N; Kollins, Scott H (2016) Topical Review: ADHD and Health-Risk Behaviors: Toward Prevention and Health Promotion. J Pediatr Psychol 41:735-40
Mitchell, John T; Sweitzer, Maggie M; Tunno, Angela M et al. (2016) ""I Use Weed for My ADHD"": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD. PLoS One 11:e0156614
Lunsford-Avery, Jessica R; Krystal, Andrew D; Kollins, Scott H (2016) Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev 50:159-174

Showing the most recent 10 out of 52 publications