Abstract

This contract is part of the NIAID's response to the global resurgence of Tuberculosis. This contract will have five components. Epidemiological studies will be performed to identify the factors which will ultimately improve our ability to design and implement tuberculosis prevention and treatment regimens. At the same time basic research efforts in immunology and microbiology will address the factors which define the """"""""stages"""""""" of disease progression as well as the factors associated with disease prevention. The clinical research component will incorporate this knowledge base in the design and conduct of Phase 1/2 clinical trials. The fifth component will coordinate all these activities to assure the success of the multidisciplinary approach of this effort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI045244-014
Application #
2489156
Study Section
Project Start
1994-09-30
Project End
1999-09-29
Budget Start
1997-03-31
Budget End
1998-09-30
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Wu, M; Aung, H; Hirsch, C S et al. (2012) Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-? in human mononuclear phagocytes. Scand J Immunol 75:301-4
Wallis, Robert S; Vinhas, Solange; Janulionis, Ernestas (2009) Strain specificity of antimycobacterial immunity in whole blood culture after cure of tuberculosis. Tuberculosis (Edinb) 89:221-4
Lewinsohn, Deborah A; Zalwango, Sarah; Stein, Catherine M et al. (2008) Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda. PLoS One 3:e3407
Theus, S; Eisenach, K; Fomukong, N et al. (2007) Beijing family Mycobacterium tuberculosis strains differ in their intracellular growth in THP-1 macrophages. Int J Tuberc Lung Dis 11:1087-93
Rojas, Roxana E; Thomas, Jeremy J; Gehring, Adam J et al. (2006) Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin. J Immunol 177:2959-68
Wallis, Robert S; Ehlers, Stefan (2005) Tumor necrosis factor and granuloma biology: explaining the differential infection risk of etanercept and infliximab. Semin Arthritis Rheum 34:34-8
Johnson, J L; Nunn, A J; Fourie, P B et al. (2004) Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis. Int J Tuberc Lung Dis 8:1348-54
Elliott, Alison M; Luzze, Henry; Quigley, Maria A et al. (2004) A randomized, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1-associated pleural tuberculosis. J Infect Dis 190:869-78
Wallis, Robert S; Kyambadde, Peter; Johnson, John L et al. (2004) A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis. AIDS 18:257-64
Wallis, Robert S; Vinhas, Solange A; Johnson, John L et al. (2003) Whole blood bactericidal activity during treatment of pulmonary tuberculosis. J Infect Dis 187:270-8

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