Abstract

The Contractor shall conduct the basic research program at the Frederick Cancer Research and Development Center. Research areas currently being pursued by Advanced BioScience Laboratories, Inc. include, inter alia, (i) eukaryotic gene expression and regulation; (ii) molecular oncology; (iii) prokaryotic and eukaryotic genetics; (iv) protein and nucleic acid chemistry; (v) chemical carcinogenesis: (vi) macromolecular structure; and (vii) x-ray crystallography.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, NCI (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CO046000-020
Application #
2658878
Study Section
Project Start
1994-09-26
Project End
1999-09-25
Budget Start
1997-09-17
Budget End
1999-01-28
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Advanced Bioscience Laboratories, Inc.
Department
Type
DUNS #
City
Kensington
State
MD
Country
United States
Zip Code
20895

  Publications

Taylor, G A; Hudson, E; Resau, J H et al. (2000) Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. J Biol Chem 275:4215-9
Kennedy, J; Vicari, A P; Saylor, V et al. (2000) A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol 67:725-34
Fujinaga, M; Cherney, M M; Tarasova, N I et al. (2000) Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog. Acta Crystallogr D Biol Crystallogr 56:272-9
Taylor, G A; Collazo, C M; Yap, G S et al. (2000) Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A 97:751-5
Gorelick, R J; Fu, W; Gagliardi, T D et al. (1999) Characterization of the block in replication of nucleocapsid protein zinc finger mutants from moloney murine leukemia virus. J Virol 73:8185-95
Webb, C P; Taylor, G A; Jeffers, M et al. (1998) Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene 17:2019-25
Geller, M; Miller, M; Swanson, S M et al. (1997) Analysis of the structure of HIV-1 protease complexed with a hexapeptide inhibitor. Part II: Molecular dynamic studies of the active site region. Proteins 27:195-203
Holz, A; Frank, M; Copeland, N G et al. (1997) Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. J Neurochem 69:1801-9
Romanov, V; Noiri, E; Czerwinski, G et al. (1997) Two novel probes reveal tubular and vascular Arg-Gly-Asp (RGD) binding sites in the ischemic rat kidney. Kidney Int 52:93-102
Reynolds, A B; Jenkins, N A; Gilbert, D J et al. (1996) The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). Genomics 31:127-9

Showing the most recent 10 out of 78 publications