Abstract

The Clinical Resource core will serve as the central facility for all clinically related activities of the Program Project Grant and is functionally divided into two sections: 1) Clinical Screening and Evaluation Section: This section will be responsible for the clinical evaluation of all members in the MEN-2A and MEN-2B and FMTC kindreds. The evaluation will include a medical history, physical examination and the tests necessary to establish the diagnosis of a specific endocrine disease state. This section will also evaluate patients who present with sporadic endocrine tumors represented in the MEN-2 and related syndromes. The procurement of all medical records on patients affected with the endocrine diseases under study will be the responsibility of this section; this includes hospital records, operative notes, pathology reports, pathology slides, paraffin blocks of fixed tissues, and diagnostic x-rays. During the screening process, biological samples will be obtained on patients and it will be the responsibility of this section to transfer them to the Laboratory Resource Core. 2) Data Analysis Section This section will serve to maintain and to analyze all data relative to clinical screening and evaluation and to linkage analysis. Specific areas of study will be determinations of penetrance, heterogeneity and segregation analysis. Also calculations of recurrence rates, disease free interval after surgery and survival rates will be determined. In addition, the linkage analysis in Research Projects 1 and 2 will be assisted by this section.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA053524-04
Application #
2338610
Study Section
Project Start
Project End
Budget Start
1994-10-01
Budget End
1995-09-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Fialkowski, Elizabeth; DeBenedetti, Mary; Moley, Jeffrey (2008) Long-term outcome of reoperations for medullary thyroid carcinoma. World J Surg 32:754-65
Skinner, Michael A; Moley, Jeffrey A; Dilley, William G et al. (2005) Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med 353:1105-13
Doherty, G M; Olson, J A; Frisella, M M et al. (1998) Lethality of multiple endocrine neoplasia type I. World J Surg 22:581-6;discussion 586-7
Yim, J H; Siegel, B A; DeBenedetti, M K et al. (1998) Prospective study of the utility of somatostatin-receptor scintigraphy in the evaluation of patients with multiple endocrine neoplasia type 1. Surgery 124:1037-42
Lowney, J K; Frisella, M M; Lairmore, T C et al. (1998) Pancreatic islet cell tumor metastasis in multiple endocrine neoplasia type 1: correlation with primary tumor size. Surgery 124:1043-8, discussion 1048-9
Herfarth, K K; Wick, M R; Marshall, H N et al. (1997) Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes Chromosomes Cancer 20:24-9
Musholt, P B; Musholt, T J; Goodfellow, P J et al. (1997) ""Cold"" single-strand conformational variants for mutation analysis of the RET protooncogene. Surgery 122:363-70; discussion 370-1
Musholt, T J; Goodfellow, P J; Scheumann, G F et al. (1997) Differential display in primary and metastatic medullary thyroid carcinoma. J Surg Res 69:94-100
Araki, T; Zimonjic, D B; Popescu, N C et al. (1997) Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J Biol Chem 272:21373-80
Tisell, L E; Dilley, W G; Wells Jr, S A (1996) Progression of postoperative residual medullary thyroid carcinoma as monitored by plasma calcitonin levels. Surgery 119:34-9

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