Abstract

The Laboratory Resource Core will serve as the central resource for the receipt of all biological samples from patients, including normal and tumor tissues, blood and urine. The samples will be catalogued and then be either used fresh in the section, disbursed to diagnostic laboratories in the General Clinical Research Center, sent to investigators in the Research Project laboratories, or cryopreserved in liquid nitrogen. The Laboratory Resource Core will prepare white cell pellets, establish lymphoblastoid cell lines (LCLs), and extract DNA from cells and tissues for use by investigators in the Research Projects. The Laboratory Resource Core will also be responsible for performing radioimmunoassay for calcitonin and carcinoembryonic antigen and other polypeptide hormones.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA053524-04
Application #
2338612
Study Section
Project Start
Project End
Budget Start
1994-10-01
Budget End
1995-09-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Fialkowski, Elizabeth; DeBenedetti, Mary; Moley, Jeffrey (2008) Long-term outcome of reoperations for medullary thyroid carcinoma. World J Surg 32:754-65
Skinner, Michael A; Moley, Jeffrey A; Dilley, William G et al. (2005) Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med 353:1105-13
Doherty, G M; Olson, J A; Frisella, M M et al. (1998) Lethality of multiple endocrine neoplasia type I. World J Surg 22:581-6;discussion 586-7
Yim, J H; Siegel, B A; DeBenedetti, M K et al. (1998) Prospective study of the utility of somatostatin-receptor scintigraphy in the evaluation of patients with multiple endocrine neoplasia type 1. Surgery 124:1037-42
Lowney, J K; Frisella, M M; Lairmore, T C et al. (1998) Pancreatic islet cell tumor metastasis in multiple endocrine neoplasia type 1: correlation with primary tumor size. Surgery 124:1043-8, discussion 1048-9
Araki, T; Zimonjic, D B; Popescu, N C et al. (1997) Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J Biol Chem 272:21373-80
Herfarth, K K; Wick, M R; Marshall, H N et al. (1997) Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes Chromosomes Cancer 20:24-9
Musholt, P B; Musholt, T J; Goodfellow, P J et al. (1997) ""Cold"" single-strand conformational variants for mutation analysis of the RET protooncogene. Surgery 122:363-70; discussion 370-1
Musholt, T J; Goodfellow, P J; Scheumann, G F et al. (1997) Differential display in primary and metastatic medullary thyroid carcinoma. J Surg Res 69:94-100
Tisell, L E; Dilley, W G; Wells Jr, S A (1996) Progression of postoperative residual medullary thyroid carcinoma as monitored by plasma calcitonin levels. Surgery 119:34-9

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