Abstract

The Genetic Diagnosis and Counseling Core will perform genotyping on patients known to be afflicted with MEN-2 and related syndromes, their spouses, and all family members at greater than 25% risk. Both PCR and RFLP analysis will be employed to detect the presence of the disease locus. The interpretation of the results will be communicated to the genetic counseling staff who will then discuss these results with the patients. This core will also provide oligonucleotides to other participants in this program project. They will be synthesized in a timely fashion on an Applied Biosystems model 394 and distributed to the various laboratories.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA053524-04
Application #
2338611
Study Section
Project Start
Project End
Budget Start
1994-10-01
Budget End
1995-09-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Fialkowski, Elizabeth; DeBenedetti, Mary; Moley, Jeffrey (2008) Long-term outcome of reoperations for medullary thyroid carcinoma. World J Surg 32:754-65
Skinner, Michael A; Moley, Jeffrey A; Dilley, William G et al. (2005) Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med 353:1105-13
Doherty, G M; Olson, J A; Frisella, M M et al. (1998) Lethality of multiple endocrine neoplasia type I. World J Surg 22:581-6;discussion 586-7
Yim, J H; Siegel, B A; DeBenedetti, M K et al. (1998) Prospective study of the utility of somatostatin-receptor scintigraphy in the evaluation of patients with multiple endocrine neoplasia type 1. Surgery 124:1037-42
Lowney, J K; Frisella, M M; Lairmore, T C et al. (1998) Pancreatic islet cell tumor metastasis in multiple endocrine neoplasia type 1: correlation with primary tumor size. Surgery 124:1043-8, discussion 1048-9
Herfarth, K K; Wick, M R; Marshall, H N et al. (1997) Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes Chromosomes Cancer 20:24-9
Musholt, P B; Musholt, T J; Goodfellow, P J et al. (1997) ""Cold"" single-strand conformational variants for mutation analysis of the RET protooncogene. Surgery 122:363-70; discussion 370-1
Musholt, T J; Goodfellow, P J; Scheumann, G F et al. (1997) Differential display in primary and metastatic medullary thyroid carcinoma. J Surg Res 69:94-100
Araki, T; Zimonjic, D B; Popescu, N C et al. (1997) Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J Biol Chem 272:21373-80
Tisell, L E; Dilley, W G; Wells Jr, S A (1996) Progression of postoperative residual medullary thyroid carcinoma as monitored by plasma calcitonin levels. Surgery 119:34-9

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