Abstract

Bioinformatics and statistics have become increasingly important in recent years as the complexity of the pathways being studied has expanded. We have three project in this PPG that are using high- throughput, genome wide analyses to generate large data sets. It is one of the roles of this core to help manage the large volumes of data being produced and make that data available in a manageable form for the members of the Stanford community, and then the rest of the scientific community as well. We will establish algorithms that can be used by the different groups to cluster expression profiles using unsupervised as well as supervised machine learning. We will also establish web-based interfaces with the Stanford community, and yeast consortium to facilitate the analysis of the homozygote deletion pool. Finally, we will work with the projects on all experiments in order to help establish exacting criteria of statistical power and significance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA067166-06
Application #
6499797
Study Section
Project Start
1996-06-15
Project End
2006-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
6
Fiscal Year
2001
Total Cost
$296,752
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Vilalta, Marta; Brune, Jourdan; Rafat, Marjan et al. (2018) The role of granulocyte macrophage colony stimulating factor (GM-CSF) in radiation-induced tumor cell migration. Clin Exp Metastasis 35:247-254
Tandon, Neha; Thakkar, Kaushik N; LaGory, Edward L et al. (2018) Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Bio Protoc 8:
Yang, Zhifen; Zhang, Jing; Jiang, Dadi et al. (2018) A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1?-XBP1 Activation. Mol Cancer Res 16:745-753
Benej, Martin; Hong, Xiangqian; Vibhute, Sandip et al. (2018) Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A 115:10756-10761
Rafat, Marjan; Aguilera, Todd A; Vilalta, Marta et al. (2018) Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Res 78:4241-4252
Saiki, Julie P; Cao, Hongbin; Van Wassenhove, Lauren D et al. (2018) Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A 115:6279-6284
Olcina, Monica M; Kim, Ryan K; Melemenidis, Stavros et al. (2018) The tumour microenvironment links complement system dysregulation and hypoxic signalling?. Br J Radiol :20180069
Jiang, Dadi; Turner, Brandon; Song, Jie et al. (2017) Comprehensive Analysis of the Unfolded Protein Response in Breast Cancer Subtypes. JCO Precis Oncol 2017:
Weyandt, Jamie D; Thompson, Craig B; Giaccia, Amato J et al. (2017) Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets. Am Soc Clin Oncol Educ Book 37:825-832
Kariolis, Mihalis S; Miao, Yu Rebecca; Diep, Anh et al. (2017) Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest 127:183-198

Showing the most recent 10 out of 203 publications