In the first four years of operation, the neuroimaging core (NC) supported scanner access, patient education and informed consent, high quality state of the art image acquisition, data transfer, storage and analysis of all UC Davis ADC related projects involving neuroimaging (MRI and PET). The core worked in close collaboration with the newly enhanced UC Davis Imaging Research Center (IRC, Director Carter) and the Imaging of Dementia and Aging (IDeA) laboratory (PI DeCarli). The interactions with the IRC allowed the core to leverage substantial institutional resources recently provided to support neurimaging research, including a research dedicated 3 Tesla MRI scanner, enhance computer resources, expanded technical support and new scientific expertise and leadership. The interactions with the IDeA laboratory provided access to state of the art software tools and computer science expertise to support the data analytic aims of the NC. Because of the availability of these new resources we will be able to provide an expanded range of services to support ADC related imaging projects during the next funding period. New tools and resources in combination with the successful recruitment of a highly diverse clinical cohort will further support the new theme of UCD ADC, which is to examine the heterogeneity of AD in a racially and ethnically diverse population. In this application for renewal of the core we propose to pursue the follwing 6 Specific Aims. 1) Support the acquisition of neuroimaging data in Alzheimer's disease (AD) and related dementias 2) Support ongoing data analyses including ongoing quantitative analyses begun during the previous funding period that focused on the analysis of white matter hyperintensities, hippocampal and cortical volumes. 3) Continue to support the Clinical and Neuropathology Cores by providing digital images or films for subjects in the subject pool and longitudinal cohort. 4) The NC will distribute and support software tools for pre-processing, analyzing and viewing results of structural imaging analysis that have been developed by the IDeA Laboratory as well as from a range of other sources.
Aim 5 : Develop and maintain data archive and retrieval system.
Aim 6 : Support the development and integration of functional MRI studies within the UCD ADC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010129-20
Application #
8078878
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
20
Fiscal Year
2010
Total Cost
$97,075
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Marino, Simeone; Xu, Jiachen; Zhao, Yi et al. (2018) Controlled feature selection and compressive big data analytics: Applications to biomedical and health studies. PLoS One 13:e0202674
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Insel, Philip S; Hansson, Oskar; Mackin, R Scott et al. (2018) Amyloid pathology in the progression to mild cognitive impairment. Neurobiol Aging 64:76-84
Riedel, Brandalyn C; Daianu, Madelaine; Ver Steeg, Greg et al. (2018) Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain. Front Aging Neurosci 10:390
Meyer, Oanh L; Leggett, Amanda; Liu, Siwei et al. (2018) Prevalence and correlates of subjective memory complaints in Vietnamese adults. Int Psychogeriatr 30:1039-1048
Swinford, Cecily G; Risacher, Shannon L; Charil, Arnaud et al. (2018) Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimers Dement (Amst) 10:322-331
Bangen, Katherine J; Preis, Sarah R; Delano-Wood, Lisa et al. (2018) Baseline White Matter Hyperintensities and Hippocampal Volume are Associated With Conversion From Normal Cognition to Mild Cognitive Impairment in the Framingham Offspring Study. Alzheimer Dis Assoc Disord 32:50-56
Fletcher, Evan; Filshtein, Teresa Jenica; Harvey, Danielle et al. (2018) Staging of amyloid ?, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses. Alzheimers Dement (Amst) 10:382-393
Meyer, Oanh L; Liu, Xiaoyan; Nguyen, Thuc-Nhi et al. (2018) Psychological Distress of Ethnically Diverse Adult Caregivers in the California Health Interview Survey. J Immigr Minor Health 20:784-791

Showing the most recent 10 out of 1156 publications