This project will provide a meta-analytic review of alcoholism treatment research published in English between 1970 and 1989. It will have three interrelated foci: examining treatment effects, identifying patient prognostic indicators, and examining patient-treatment matching effects. Analyses of studies in each of these three areas will proceed in six stages: (a) describing the characteristics of studies, (b) aggregating significance levels across studies; (c) computing individual indices of effect magnitude, (d) testing the homogeneity of effect magnitudes, (e) computing and testing the significance of average effect magnitudes, and (f) accounting for variation in effect magnitudes across studies. The review will reveal the topography of alcoholism treatment research over the past 20 years, including the extent to which such research incorporates the features of state-of-the-art treatment research and whether the state-of-the-art is being more closely approximated over time. In addition, the review will determine (a) whether treatment effects estimates vary as a function of research design, outcome dimension tapped, measures used, etc.; (b) the extent to which research has been underpowered and thus has yielded misleading no-difference findings in comparisons of different treatment modalities; and (c) the effect sizes and levels of during-treatment and during-study patient attrition that are likely with different treatment approaches. Substantively, the review will determine (a) the quantitative effects of treatment versus no minimal treatment; (b) the relative effects of different treatment approaches; (c) the extent to which treatment effects decay over time; (d) the extent to which uncontrolled patient population differences across studies may have led to misleading conclusions in prior reviews regarding the superiority of specific treatment modalities; (e) the patient characteristics that are predictive of positive outcome in general, as well as within specific treatment modalities; (f) an equation a la Costello (1980) for predicting treatment outcome given basic information on patient and treatment characteristics; and (g) the effects of patient-treatment matching efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA008689-03
Application #
2044738
Study Section
Clinical and Treatment Subcommittee (ALCP)
Project Start
1990-09-28
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1994-08-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Palo Alto Institute for Research & Edu, Inc.
Department
Type
DUNS #
624218814
City
Palo Alto
State
CA
Country
United States
Zip Code
94304
Blodgett, Janet C; Del Re, A C; Maisel, Natalya C et al. (2014) A meta-analysis of topiramate's effects for individuals with alcohol use disorders. Alcohol Clin Exp Res 38:1481-8
Blodgett, Janet C; Maisel, Natalya C; Fuh, Ingrid L et al. (2014) How effective is continuing care for substance use disorders? A meta-analytic review. J Subst Abuse Treat 46:87-97
Humphreys, Keith; Maisel, Natalya C; Blodgett, Janet C et al. (2013) Representativeness of patients enrolled in influential clinical trials: a comparison of substance dependence with other medical disorders. J Stud Alcohol Drugs 74:889-93
Del Re, A C; Maisel, Natalya; Blodgett, Janet C et al. (2013) Placebo group improvement in trials of pharmacotherapies for alcohol use disorders: a multivariate meta-analysis examining change over time. J Clin Psychopharmacol 33:649-57
Humphreys, Keith; Maisel, Natalya C; Blodgett, Janet C et al. (2013) Extent and reporting of patient nonenrollment in influential randomized clinical trials, 2002 to 2010. JAMA Intern Med 173:1029-31
Maisel, Natalya C; Blodgett, Janet C; Wilbourne, Paula L et al. (2013) Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful? Addiction 108:275-93
Del Re, A C; Maisel, Natalya; Blodgett, Janet et al. (2013) The declining efficacy of naltrexone pharmacotherapy for alcohol use disorders over time: a multivariate meta-analysis. Alcohol Clin Exp Res 37:1064-8
Finney, John W; Hagedorn, Hildi J (2011) Introduction to a special section on implementing evidence-based interventions for substance use disorders. Psychol Addict Behav 25:191-3
Manuel, Jennifer K; Hagedorn, Hildi J; Finney, John W (2011) Implementing evidence-based psychosocial treatment in specialty substance use disorder care. Psychol Addict Behav 25:225-37
Moos, Rudolf H; Finney, John W (2011) Commentary on Lopez-Quintero et al. (2011): Remission and relapse - the Yin-Yang of addictive disorders. Addiction 106:670-1

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