Research on alcoholism treatment outcome is expanding at an ever-increasing rate. Periodic reviews are needed to take stock of what has been accomplished in the past and to point to productive directions for future research. This application proposes to continue a comprehensive, quantitative review of the alcoholism treatment outcome research literature. The proposed syntheses will have three foci: (a) the relative effectiveness of different treatment modalities; (b) the effects of potential prognostic indicators (i.e., patient characteristics assessed at treatment intake as they relate to posttreatment functioning); and (c) patient-treatment interaction effects (i.e. whether different types of patients experience better outcomes in different types of treatment). Each of these foci is of interest in its own right and all are related in that they provide information relevant to the issue of patient-treatment matching. The proposed project will add to an existing dataset so that it will be possible to describe the nature of alcoholism treatment research over a 29-year period and the extent to which it reflects various components of methodological quality (e.g. rigorous research design). It also will be possible to determine whether the methodological quality of alcoholism treatment outcome studies has been increasing over time. In addition, the review will provide evidence on the extent to which research has been underpowered. The proposed work will break new ground in research synthesis techniques with respect to estimating the effectiveness of treatment. Because the body of comparative treatment research in the alcohol field contains no consistent, standard treatment or control condition, a traditional meta-analysis with between-group effect sizes is neither applicable nor meaningful. Consequently, alternative approaches will be used to estimate the magnitude of effects of different treatment modalities. In developing and applying alternative techniques, we will build on our previous efforts to (a) do focused comparisons of alternative treatment modalities; (b) adjust box-score indices of treatment effectiveness by taking into account the """"""""strength of the competition"""""""" against which different modalities have been pitted; and (c) model abstinence and """"""""success"""""""" (abstinence plus nonproblem drinking) rates across studies. However, we propose to apply these approaches using between-and within-treatment-group effects sizes instead of box-score effectiveness indices, and in addition to simple rates of abstinence and """"""""success.""""""""

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA008689-06
Application #
2732436
Study Section
Clinical and Treatment Subcommittee (ALCP)
Project Start
1990-09-28
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Palo Alto Institute for Research & Edu, Inc.
Department
Type
DUNS #
624218814
City
Palo Alto
State
CA
Country
United States
Zip Code
94304
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Blodgett, Janet C; Maisel, Natalya C; Fuh, Ingrid L et al. (2014) How effective is continuing care for substance use disorders? A meta-analytic review. J Subst Abuse Treat 46:87-97
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Del Re, A C; Maisel, Natalya; Blodgett, Janet C et al. (2013) Placebo group improvement in trials of pharmacotherapies for alcohol use disorders: a multivariate meta-analysis examining change over time. J Clin Psychopharmacol 33:649-57
Humphreys, Keith; Maisel, Natalya C; Blodgett, Janet C et al. (2013) Extent and reporting of patient nonenrollment in influential randomized clinical trials, 2002 to 2010. JAMA Intern Med 173:1029-31
Maisel, Natalya C; Blodgett, Janet C; Wilbourne, Paula L et al. (2013) Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful? Addiction 108:275-93
Del Re, A C; Maisel, Natalya; Blodgett, Janet et al. (2013) The declining efficacy of naltrexone pharmacotherapy for alcohol use disorders over time: a multivariate meta-analysis. Alcohol Clin Exp Res 37:1064-8
Finney, John W; Hagedorn, Hildi J (2011) Introduction to a special section on implementing evidence-based interventions for substance use disorders. Psychol Addict Behav 25:191-3
Manuel, Jennifer K; Hagedorn, Hildi J; Finney, John W (2011) Implementing evidence-based psychosocial treatment in specialty substance use disorder care. Psychol Addict Behav 25:225-37
Moos, Rudolf H; Finney, John W (2011) Commentary on Lopez-Quintero et al. (2011): Remission and relapse - the Yin-Yang of addictive disorders. Addiction 106:670-1

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