While the field of translational research is gaining increased attention, few teams have successfully integrated brain+behavioral approaches to examine the developing adolescent brain in the context of addiction treatment. PI Feldstein Ewing has been at the forefront of this work, highlighting that in contrast to adults who show reduced reward response in mesocorticolimbic regions during addiction treatment, adolescents' addiction behavior change revolves around enhanced default mode network response [DMN; precuneus, posterior cingulate gyrus (PCC), and middle frontal gyrus (MFG)]. Our foundational studies underscore in this age group, greater DMN response during critical elements of treatment (client language; therapist language) corresponds with greater behavior change (less problem drinking). Our foundational studies have also critically advanced neurodevelopmental addiction theory, illuminating 4 neuro-biobehavioral drivers of adolescent addiction treatment response, including innovative behavioral treatment approaches that planfully integrate a neurodevelopmental perspective and engage: (a) prosocial (vs. problem-based) approaches, (b) adolescents' drastically developing cognitive skills, (c) adolescents' developmentally-specific drive for autonomy, and (d) parents into programming. Following our team's established track record in adolescent intervention development, we aim to use the opportunity of this competitive continuation to maximize our formative translational (brain+behavioral) developmental neuroscience data and theory to inform the creation of a novel behavioral treatment for adolescent addiction (JUNO: Jumpstart Understanding of Neurodevelopmental Opportunity). This competitive continuation directly responds to NOT-AA-19-010's 2019 Notice Interest: of Special development and dissemination of behavioral treatments for alcohol use disorder.? Here,we propose to merge quantitative neurodevelopmental data from the 1st 4 years of this project with qualitative data from adolescent focus groups (Aim 1), to create a tailored for drinking neurodevelopmentally-responsive behavioral treatment youth (JUNO). We will then evaluate initial impact of this novel behavioral treatment on adolescent problem and proposed neurodevelopmental mechanisms (Aim 2).
At this time, most American youth have consumed alcohol, with many engaging in binge drinking, one of the highest risk patterns of consumption; while existing interventions show promise, they do not work universally well for all youth. Thus,in this competitive continuation,we propose to merge quantitative neurodevelopmental data from the 1st 4 years of this project with qualitative data from adolescent focus groups, to create a tailored neurodevelopmentally-responsive this behavioral treatment for youth (JUNO). We will then evaluate initial impact of novel behavioral treatment on adolescent problem drinking and proposed neurodevelopmentalmechanisms.
| Dash, Genevieve F; Wilson, Anna C; Morasco, Benjamin J et al. (2018) A Model of the Intersection of Pain and Opioid Misuse in Children and Adolescents. Clin Psychol Sci 6:629-646 |
| Cousijn, Janna; Luijten, Maartje; Feldstein Ewing, Sarah W (2018) Adolescent resilience to addiction: a social plasticity hypothesis. Lancet Child Adolesc Health 2:69-78 |
| Rømer Thomsen, Kristine; Blom Osterland, Tine; Hesse, Morten et al. (2018) The intersection between response inhibition and substance use among adolescents. Addict Behav 78:228-230 |
| Rømer Thomsen, Kristine; Callesen, Mette Buhl; Feldstein Ewing, Sarah W (2017) Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior. Neurosci Biobehav Rev 80:156-158 |
| Caouette, Justin D; Feldstein Ewing, Sarah W (2017) Four Mechanistic Models of Peer Influence on Adolescent Cannabis Use. Curr Addict Rep 4:90-99 |
| Feldstein Ewing, Sarah W; Chung, Tammy; Caouette, Justin D et al. (2017) Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. Neuroimage 151:14-23 |
| Feldstein Ewing, Sarah W; Lovejoy, Travis I; Choo, Esther K (2017) How Has Legal Recreational Cannabis Affected Adolescents in Your State? A Window of Opportunity. Am J Public Health 107:246-247 |
| Choo, Esther K; Feldstein Ewing, Sarah W; Lovejoy, Travis I (2016) Opioids Out, Cannabis In: Negotiating the Unknowns in Patient Care for Chronic Pain. JAMA 316:1763-1764 |
| Feldstein Ewing, Sarah W; Apodaca, Timothy R; Gaume, Jacques (2016) Ambivalence: Prerequisite for success in motivational interviewing with adolescents? Addiction 111:1900-1907 |
| Feldstein Ewing, Sarah W; Tapert, Susan F; Molina, Brooke S G (2016) Uniting adolescent neuroimaging and treatment research: Recommendations in pursuit of improved integration. Neurosci Biobehav Rev 62:109-14 |
Showing the most recent 10 out of 12 publications
