Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033332-02
Application #
2068334
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1993-06-01
Project End
1996-05-31
Budget Start
1994-06-01
Budget End
1995-05-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Porcari, Anthony R; Townsend, Leroy B (2004) An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. Nucleosides Nucleotides Nucleic Acids 23:31-9
Porcari, Anthony R; Ptak, Roger G; Borysko, Katherine Z et al. (2003) Synthesis and antiviral activity of 2-substituted analogs of triciribine. Nucleosides Nucleotides Nucleic Acids 22:2171-93
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Porcari, A R; Townsend, L B (1999) Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures. Nucleosides Nucleotides 18:153-9
Porcari, A R; Devivar, R V; Kucera, L S et al. (1998) Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. J Med Chem 41:1252-62
Ptak, R G; Borysko, K Z; Porcari, A R et al. (1998) Phosphorylation of triciribine is necessary for activity against HIV type 1. AIDS Res Hum Retroviruses 14:1315-22
Hoops, G C; Townsend, L B; Garcia, G A (1995) tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1. Biochemistry 34:15381-7
Hoops, G C; Townsend, L B; Garcia, G A (1995) Mechanism-based inactivation of tRNA-guanine transglycosylase from Escherichia coli by 2-amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4 (3H)-one. Biochemistry 34:15539-44