Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036550-03
Application #
2072895
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1994-08-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Rosenzweig, M; Marks, D F; DeMaria, M A et al. (2001) Identification of primitive hematopoietic progenitor cells in the rhesus macaque. J Med Primatol 30:36-45
Kaur, A; Rosenzweig, M; Johnson, R P (2000) Immunological memory and acquired immunodeficiency syndrome pathogenesis. Philos Trans R Soc Lond B Biol Sci 355:381-90
Rosenzweig, M; DeMaria, M A; Harper, D M et al. (1998) Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Proc Natl Acad Sci U S A 95:6388-93
Rosenzweig, M; Marks, D F; Hempel, D et al. (1997) Transduction of CD34+ hematopoietic progenitor cells with an antitat gene protects T-cell and macrophage progeny from AIDS virus infection. J Virol 71:2740-6
Rosenzweig, M; Pykett, M; Marks, D F et al. (1997) Enhanced maintenance and retroviral transduction of primitive hematopoietic progenitor cells using a novel three-dimensional culture system. Gene Ther 4:928-36
Goodell, M A; Rosenzweig, M; Kim, H et al. (1997) Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3:1337-45
Rosenzweig, M; Marks, D F; Hempel, D et al. (1997) Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection. Blood 90:4822-31
Rosenzweig, M; Marks, D F; Zhu, H et al. (1996) In vitro T lymphopoiesis of human and rhesus CD34+ progenitor cells. Blood 87:4040-8
Rosenzweig, M; Marks, D F; Hempel, D et al. (1996) In vitro T lymphopoiesis: a model system for stem cell gene therapy for AIDS. J Med Primatol 25:192-200
Wilson, C C; Wong, J T; Girard, D D et al. (1995) Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents. J Infect Dis 172:88-96