Antibodies in the Antiphospholipid Syndrome - Pojen Chen

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type: Research Project (R01)
Project #: 1R01AR042506-01A2
Application #: 2081819
Study Section: Special Emphasis Panel (ZRG4-GMA-2 (01))

Project Start: 1996-02-25
Project End: 1998-11-30
Budget Start: 1996-02-25
Budget End: 1996-11-30
Support Year: 1
Fiscal Year: 1996
Total Cost
Indirect Cost

Institution

Name: University of California San Diego
Department: Internal Medicine/Medicine
Type: Schools of Medicine
DUNS #: 077758407

City: La Jolla
State: CA
Country: United States
Zip Code: 92093

Related projects


NIH 2007 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$257,830
NIH 2006 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$265,530
NIH 2005 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$271,480
NIH 2004 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$269,720
NIH 2002 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$251,685
NIH 2001 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$251,685
NIH 2000 R01 AR	Anticardiolipin Antibodies in Antiphospholipid Syndrome Chen, Pojen P. / University of California Los Angeles	$251,685
NIH 1998 R01 AR	Chen, Pojen P. / University of California Los Angeles
NIH 1997 R01 AR	Chen, Pojen P. / University of California San Diego
NIH 1996 R01 AR	Antibodies in the Antiphospholipid Syndrome Chen, Pojen P. / University of California San Diego

Publications

Chen, P P; Wu, M; Hahn, B H (2010) Some antiphospholipid antibodies bind to various serine proteases in hemostasis and tip the balance toward hypercoagulant states. Lupus 19:365-9

Yang, Yao-Hsu; Chien, Daniel; Wu, Meifang et al. (2009) Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin. J Immunol 182:1674-80

Ede, Kaleo; Hwang, Kwan-Ki; Wu, Chen-Ching et al. (2009) Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice. Arthritis Rheum 60:3108-17

Pierangeli, Silvia S; Chen, Pojen P; Raschi, Elena et al. (2008) Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost 34:236-50

Chen, P P; Yang, C D; Ede, K et al. (2008) Some antiphospholipid antibodies bind to hemostasis and fibrinolysis proteases and promote thrombosis. Lupus 17:916-21

Lin, Wei-Shiang; Chen, Pei-Chih; Yang, Cheng-De et al. (2007) Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 56:1638-47

Chen, Xiao-Xiang; Gu, Yue-Ying; Li, Shu-Jie et al. (2007) Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice. J Immunol 178:5351-6

Vega-Ostertag, Mariano; Liu, Xiaowei; Kwan-Ki, Hwang et al. (2006) A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells. Br J Haematol 135:214-9

Yang, Yao-Hsu; Hwang, Kwan-Ki; FitzGerald, John et al. (2006) Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin. J Immunol 177:8219-25

Lu, Cai-Sheng; Horizon, Arash A; Hwang, Kwan-Ki et al. (2005) Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 52:4018-27

Showing the most recent 10 out of 21 publications

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