Aim 1 is to generate and characterize 10 IgG monoclonal aCLs.
Aim 2 is to analyze monoclonal aCLs in the in vivo fetal loss model.
Aim 3 is to identify and characterize the mimetics for pathogenic aCL.
Aim 4 is to do immunological and functional studies of antibodies against mimetics in APS patients.
Aim 5 is to apply mimetics to study pathogenic aCL in APS patients and controls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042506-05
Application #
6374981
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Serrate-Sztein, Susana
Project Start
1996-02-25
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
5
Fiscal Year
2001
Total Cost
$251,685
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Yang, Yao-Hsu; Chien, Daniel; Wu, Meifang et al. (2009) Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin. J Immunol 182:1674-80
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Lu, Cai-Sheng; Horizon, Arash A; Hwang, Kwan-Ki et al. (2005) Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 52:4018-27

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