The long term objectives of this research are to facilitate research into the genetic etiology of cancer by providing core support for (1) developing statistical models to analyze familial dependencies in pedigree data, (2) preparing a package of computer programs based on these models, (3) preparing clear and comprehensive documentation on the use and structure of these programs, and (4) performing simulation experiments to examine the validity, power, efficiency and robustness of these programs to elucidate etiological mechanisms in cancer family data. Segregation and linkage analysis programs will be based on the new regressive models, both univariate and multivariate, which lend themselves to fast computational algorithms. Logistic regression analysis will be extended to be appropriate for the dependencies that occur in family data. Computer programs will be written to be user-friendly, in standard ANSI X3.9 (FORTRAN 77), and carefully documented with the user in mind. Computer simulation will be used to investigate those statistical properties of the methods developed that cannot be determined analytically.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028198-10
Application #
3168028
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1980-03-01
Project End
1990-08-31
Budget Start
1989-03-01
Budget End
1990-08-31
Support Year
10
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Bailey-Wilson, J E; Sellers, T A; Elston, R C et al. (1993) Evidence for a major gene effect in early-onset lung cancer. J La State Med Soc 145:157-62
Bailey-Wilson, J E; Bamba, V (1993) Sib-pair linkage analyses of Alzheimer's disease. Genet Epidemiol 10:371-6
Bailey-Wilson, J E; Dobbins, T E (1992) Sib-pair linkage analysis applied to pedigrees with melanoma and dysplastic nevi. Cytogenet Cell Genet 59:176-8
Sellers, T A; Bailey-Wilson, J E; Elston, R C et al. (1990) Evidence for mendelian inheritance in the pathogenesis of lung cancer. J Natl Cancer Inst 82:1272-9
Elston, R C; George, V T (1989) Age of onset, age at examination, and other covariates in the analysis of family data. Genet Epidemiol 6:217-20
Bailey-Wilson, J E; Elston, R C; Wilson, A F et al. (1989) A comparison of some sib-pair linkage methods and multiple locus extensions. Prog Clin Biol Res 329:129-34
Amos, C I; Elston, R C; Keats, B J (1989) Information for detecting linkage when sampling affected individuals. Prog Clin Biol Res 329:207-12
Sellers, T A; Ooi, W L; Elston, R C et al. (1987) Increased familial risk for non-lung cancer among relatives of lung cancer patients. Am J Epidemiol 126:237-46
Lin, M F; Bailey-Wilson, J E; Elston, R C et al. (1987) Developmental expression of tyrosyl kinase activity in human serum. Hum Biol 59:549-56
Bonney, G E (1987) Logistic regression for dependent binary observations. Biometrics 43:951-73

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