Abstract

Biostatistical methodology is in a race to keep up with the massive databases being accumulated by new biomedical technologies. The long-term purpose of this grant has been to shorten the transfer time between modern statistical theory and its successful application to practice. The three new projects proposed here each use computer-intensive theoretical ideas to attack a difficult applications area: empirical Bayes methods for the analysis of microarray data; two way proportional hazards modeling for disentangling complicated survival situations that arise in cancer and HIV studies; and new permutation and bootstrap methods for assessing genotype-phenotype relationships in large association studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA059039-27
Application #
6430717
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (01))
Program Officer
Erickson, Burdette (BUD) W
Project Start
1993-01-15
Project End
2004-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
27
Fiscal Year
2002
Total Cost
$178,830
Indirect Cost

  Institution

Name
Stanford University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Rath, Barbara A; Yousef, Kaveh Pouran; Katzenstein, David K et al. (2013) In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis. PLoS One 8:e61102
Rath, Barbara A; Olshen, Richard A; Halpern, Jerry et al. (2012) Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance. Viruses 4:1212-34
Bhamre, S; Nuzzo, R L; Whitin, J C et al. (2000) Intracellular reduction of selenite into glutathione peroxidase. Evidence for involvement of NADPH and not glutathione as the reductant. Mol Cell Biochem 211:17-Sep
Lin, A; Lenert, L A; Hlatky, M A et al. (1999) Clustering and the design of preference-assessment surveys in healthcare. Health Serv Res 34:1033-45
Sugar, C A; Sturm, R; Lee, T T et al. (1998) Empirically defined health states for depression from the SF-12. Health Serv Res 33:911-28
Buckheit, J B; Olshen, R A; Blouch, K et al. (1997) Modeling of progressive glomerular injury in humans with lupus nephritis. Am J Physiol 273:F158-69
Lech, W J; Wang, G; Yang, Y L et al. (1996) In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol 70:2038-43
Bickel, P J; Cosman, P C; Olshen, R A et al. (1996) Covariability of V3 loop amino acids. AIDS Res Hum Retroviruses 12:1401-11
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:7085-90
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:13429-34

Showing the most recent 10 out of 11 publications