The long-term goal of this research grant is to bring new developments in statistical theory and methodology to bear on the practical problems of biostatistics and medicine. The researchers pursue this goal from their joint positions in the Stanford medical school, where they work on specific biostatistical projects, and the development and review. Research on the grant involves the creation of new statistical methods, study of new and existing techniques through mathematical analysis and computer simulation, and trial applications of these procedures to ongoing research projects at the medical school. The following five areas will be the focus of the research: (1) bootstrap methods, (2) recursive partitioning and classification trees, (3) modern regression methods and their extensions, (4) image reconstruction methods, (5) hazard rates and censored data. Successful new statistical methodology finds application across a wide spectrum of biomedical applications. On the basis of past experience, the topics studied here will be particularly useful in cancer therapy clinical trials, cardiovascular research, and areas like gait analysis where diagnostic measures tend to have very complicated structure.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA059039-19
Application #
2099684
Study Section
Special Emphasis Panel (SSS (R2))
Project Start
1993-01-15
Project End
1995-12-31
Budget Start
1994-02-01
Budget End
1994-12-31
Support Year
19
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Stanford University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Rath, Barbara A; Yousef, Kaveh Pouran; Katzenstein, David K et al. (2013) In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis. PLoS One 8:e61102
Rath, Barbara A; Olshen, Richard A; Halpern, Jerry et al. (2012) Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance. Viruses 4:1212-34
Bhamre, S; Nuzzo, R L; Whitin, J C et al. (2000) Intracellular reduction of selenite into glutathione peroxidase. Evidence for involvement of NADPH and not glutathione as the reductant. Mol Cell Biochem 211:17-Sep
Lin, A; Lenert, L A; Hlatky, M A et al. (1999) Clustering and the design of preference-assessment surveys in healthcare. Health Serv Res 34:1033-45
Sugar, C A; Sturm, R; Lee, T T et al. (1998) Empirically defined health states for depression from the SF-12. Health Serv Res 33:911-28
Buckheit, J B; Olshen, R A; Blouch, K et al. (1997) Modeling of progressive glomerular injury in humans with lupus nephritis. Am J Physiol 273:F158-69
Lech, W J; Wang, G; Yang, Y L et al. (1996) In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol 70:2038-43
Bickel, P J; Cosman, P C; Olshen, R A et al. (1996) Covariability of V3 loop amino acids. AIDS Res Hum Retroviruses 12:1401-11
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:7085-90
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:13429-34

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