Abstract

Useful statistical ideas are drawn into biomedical practice from a wide range of sources, including theoretical research and developments in other application areas. The long-term purpose of this grant is to speed the transfer of promising new statistical technology into health- related applications.
Five specific aims are proposed here, all of which involve a combination of computer-intensive methodology with new developments in statistical theory. Bootstrap and permutation methods are suggested for some specific biomedical problems: in the analysis of accuracy measurements for medical images, and also for chromosomal ordering via radiation hybrids. More general problems of the types encountered in biostatistical work are also under investigation: setting accurate confidence intervals, assessing the accuracy of discrete estimates such as phylogenetic trees, and making use of Bayesian ideas in an objective manner. The investigation pursues these topics from several vantage points, the Stanford statistics department, the medical school, and the Human Genome project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA059039-24
Application #
2745176
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Erickson, Burdette (BUD) W
Project Start
1993-01-15
Project End
2001-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
24
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Rath, Barbara A; Yousef, Kaveh Pouran; Katzenstein, David K et al. (2013) In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis. PLoS One 8:e61102
Rath, Barbara A; Olshen, Richard A; Halpern, Jerry et al. (2012) Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance. Viruses 4:1212-34
Bhamre, S; Nuzzo, R L; Whitin, J C et al. (2000) Intracellular reduction of selenite into glutathione peroxidase. Evidence for involvement of NADPH and not glutathione as the reductant. Mol Cell Biochem 211:17-Sep
Lin, A; Lenert, L A; Hlatky, M A et al. (1999) Clustering and the design of preference-assessment surveys in healthcare. Health Serv Res 34:1033-45
Sugar, C A; Sturm, R; Lee, T T et al. (1998) Empirically defined health states for depression from the SF-12. Health Serv Res 33:911-28
Buckheit, J B; Olshen, R A; Blouch, K et al. (1997) Modeling of progressive glomerular injury in humans with lupus nephritis. Am J Physiol 273:F158-69
Lech, W J; Wang, G; Yang, Y L et al. (1996) In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol 70:2038-43
Bickel, P J; Cosman, P C; Olshen, R A et al. (1996) Covariability of V3 loop amino acids. AIDS Res Hum Retroviruses 12:1401-11
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:7085-90
Efron, B; Halloran, E; Holmes, S (1996) Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A 93:13429-34

Showing the most recent 10 out of 11 publications