Physiology and Pharmacology of Opioids in Brain - Carl Lupica

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Institute on Drug Abuse (NIDA)
Type: Research Project (R01)
Project #: 5R01DA007725-05
Application #: 2120217
Study Section: Drug Abuse Biomedical Research Review Committee (DABR)

Project Start: 1992-07-01
Project End: 2000-06-30
Budget Start: 1996-07-01
Budget End: 1997-06-30
Support Year: 5
Fiscal Year: 1996
Total Cost
Indirect Cost

Institution

Name: University of Colorado Denver
Department: Pharmacology
Type: Schools of Medicine
DUNS #: 065391526

City: Aurora
State: CO
Country: United States
Zip Code: 80045

Related projects


NIH 2001 R01 DA	Physiology and Pharmacology of Opioids in Brain French, Edward D. / University of Arizona	$142,611
NIH 1998 R01 DA	Physiology and Pharmacology of Opioids in Brain Lupica, Carl R. / University of Arizona
NIH 1997 R01 DA	Physiology and Pharmacology of Opioids in Brain Lupica, Carl R. / University of Colorado Denver
NIH 1996 R01 DA	Physiology and Pharmacology of Opioids in Brain Lupica, Carl R. / University of Colorado Denver
NIH 1995 R01 DA	Physiology and Pharmacology of Opioids in Brain Lupica, Carl R. / University of Colorado Denver
NIH 1994 R01 DA	Opioid Action in Hippocampus Lupica, Carl R. / University of Colorado Denver
NIH 1993 R01 DA	Opioid Action in Hippocampus Lupica, Carl R. / University of Colorado Denver
NIH 1992 R01 DA	Opioid Action in Hippocampus Lupica, Carl R. / University of Colorado Denver

Publications

Lupica, C R; Bell, J A; Hoffman, A F et al. (2001) Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. J Neurophysiol 86:261-8

Svoboda, K R; Adams, C E; Lupica, C R (1999) Opioid receptor subtype expression defines morphologically distinct classes of hippocampal interneurons. J Neurosci 19:85-95

Svoboda, K R; Lupica, C R (1998) Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents. J Neurosci 18:7084-98

Miller, K K; Hoffer, A; Svoboda, K R et al. (1997) Cholecystokinin increases GABA release by inhibiting a resting K+ conductance in hippocampal interneurons. J Neurosci 17:4994-5003

Miller, K K; Lupica, C R (1997) Neuropeptide FF inhibition of morphine effects in the rat hippocampus. Brain Res 750:81-6

Lupica, C R (1995) Delta and mu enkephalins inhibit spontaneous GABA-mediated IPSCs via a cyclic AMP-independent mechanism in the rat hippocampus. J Neurosci 15:737-49

Miller, K K; Lupica, C R (1994) Morphine-induced excitation of pyramidal neurons is inhibited by cholecystokinin in the CA1 region of the rat hippocampal slice. J Pharmacol Exp Ther 268:753-61

Lupica, C R; Proctor, W R; Dunwiddie, T V (1992) Dissociation of mu and delta opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro. Brain Res 593:226-38

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