Marijuana is the most widely used illicit drug in the United States today, with over 5 million individuals reports use within the last 20 days. Decision making is required for behaviors ranging from simple motor movements to complex reasoning about future consequences. A recent report from our lab has shown that marijuana users have impaired decision making as measured by the Iowa Gambling Task, a laboratory- based decision making task. Marijuana users, as compared to controls, made significantly more risky choices. Furthermore, mathematical modeling of these data has suggested that marijuana users perform poorly because they have deficient cognitive and response style processes. The overall goal of this application, then, is to isolate the specific processes underlying the poor performance of marijuana users by investigating performance on tasks specific to each of these two processes. In the proposed studies recent heavy marijuana users will be compared to non-using controls on performance of an N-back task, a test of working memory and a GO/NOGO task, a test of impulsive response style, as well as the Gambling Task. In addition, functional magnetic resonance imaging (fMRI) will be used to examine brain activity during the performance of these three tasks. Discriminant analyses will be used to distinguish the relationship among performance measures in an effort to identify the root causes of deficient decision-making in this population. We will also relate patterns of brain activity to performance variables and to each other to look for common elements across patterns. This will provide information about the underlying neural processes associated with, chronic marijuana use. Because marijuana is often thought to be less risky than other abused drugs, its potential deleterious effects are often ignored or unrecognized. Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA020074-02
Application #
7221306
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Grant, Steven J
Project Start
2006-04-10
Project End
2009-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
2
Fiscal Year
2007
Total Cost
$282,161
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Wesley, Michael J; Lile, Joshua A; Fillmore, Mark T et al. (2017) Neurophysiological capacity in a working memory task differentiates dependent from nondependent heavy drinkers and controls. Drug Alcohol Depend 175:24-35
Wesley, Michael J; Lile, Joshua A; Hanlon, Colleen A et al. (2016) Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation. Psychopharmacology (Berl) 233:1035-44
Moussa, Malaak N; Simpson, Sean L; Mayhugh, Rhiannon E et al. (2014) Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci 6:341
Moussa, Malaak Nasser; Wesley, Michael J; Porrino, Linda J et al. (2014) Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Brain Connect 4:193-202
Cousijn, Janna; Wiers, Reinout W; Ridderinkhof, K Richard et al. (2013) Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. Addict Biol 18:1013-23
Hanlon, Colleen A; Wesley, Michael J; Stapleton, Jennifer R et al. (2011) The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend 115:240-3
Hanlon, Colleen A; Dufault, Darin L; Wesley, Michael J et al. (2011) Elevated gray and white matter densities in cocaine abstainers compared to current users. Psychopharmacology (Berl) 218:681-92
Wesley, Michael J; Hanlon, Colleen A; Porrino, Linda J (2011) Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Res 191:51-9
Hanlon, Colleen A; Wesley, Michael J; Roth, Alicia J et al. (2010) Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control. Psychiatry Res 181:15-23
Hanlon, Colleen A; Wesley, Michael J; Porrino, Linda J (2009) Loss of functional specificity in the dorsal striatum of chronic cocaine users. Drug Alcohol Depend 102:88-94

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