This proposal represents a continuation of a long-term project with the development of a coherent understanding of the factors responsible for altering thyroid hormone production, metabolism, delivery and disposal in states of thyroid hormone deficiency and excess, systemic illnesses, fasting and undernutrition in man. Particular areas of investigation include: 1) The determination of the mechanisms responsible for maintaining triiodothyronine blood levels by altering peripheral tissue thyroxine to triiodothyronine conversion in states of thyroxine deficiency or excess. 2) Evaluation of the metabolic consequences of altered circulating thyroid hormone levels which occur with fasting and undernutrition. 3) Determination of the major tissues and organs which are responsible for the in vivo production of triiodothyronine and reverse triiodothyronine from thyroxine. 4) Investigation of the humoral signals which appear responsible for altering free thyroxine levels, the efficiency of conversion of thyroxine to triiodothyronine and the inhibition of pituitary TSH release in fasting and nonthyroidal illnesses. 5) Determination of the mechanisms responsible for producing nonthyroid hormone suppressible thyroxine secretion by the thyroid gland in normal subjects and possible alterations which may occur in patients with nontoxic goiter, thyroid glandular injury resulting from X-ray therapy, and in certain subjects with obesity. Although some animal studies are proposed in this grant, the principal focus will be on human subjects with the view that unique differences in the regulatory control mechanisms for thyroid hormone metabolism occur in man.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK011727-18
Application #
3224810
Study Section
Endocrinology Study Section (END)
Project Start
1976-12-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
18
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Spencer, C A (2000) Serum thyroglobulin measurements: clinical utility and technical limitations in the management of patients with differentiated thyroid carcinomas. Endocr Pract 6:481-4
Spencer, C A; LoPresti, J S; Fatemi, S et al. (1999) Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid 9:435-41
Spencer, C A; Takeuchi, M; Kazarosyan, M et al. (1998) Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 83:1121-7
Spencer, C A; Takeuchi, M; Kazarosyan, M (1996) Current status and performance goals for serum thyroglobulin assays. Clin Chem 42:164-73
Spencer, C A (1996) Dynamics of thyroid hormone suppression of serum thyrotropin: an invited commentary. Eur J Endocrinol 135:285-6
Spencer, C A (1996) Recoveries cannot be used to authenticate thyroglobulin (Tg) measurements when sera contain Tg autoantibodies. Clin Chem 42:661-3
Spencer, C A; Takeuchi, M; Kazarosyan, M (1996) Current status and performance goals for serum thyrotropin (TSH) assays. Clin Chem 42:140-5
Spencer, C A; Wang, C C (1995) Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls. Endocrinol Metab Clin North Am 24:841-63
Spencer, C A; Takeuchi, M; Kazarosyan, M et al. (1995) Interlaboratory/intermethod differences in functional sensitivity of immunometric assays of thyrotropin (TSH) and impact on reliability of measurement of subnormal concentrations of TSH. Clin Chem 41:367-74
Spencer, C A; LoPresti, J S; Nicoloff, J T et al. (1995) Multiphasic thyrotropin responses to thyroid hormone administration in man. J Clin Endocrinol Metab 80:854-9

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