Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK019155-21
Application #
2137273
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1977-09-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Pathology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Ellerman, K E; Like, A A (2000) Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43:890-8
Ellerman, K E; Like, A A (1999) Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat. Diabetes 48:975-82
Ellerman, K E; Richards, C A; Guberski, D L et al. (1996) Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat. Diabetes 45:557-62
Ellerman, K E; Like, A A (1995) A major histocompatibility complex class II restriction for BioBreeding/Worcester diabetes-inducing T cells. J Exp Med 182:923-30
Stubbs, M; Guberski, D L; Like, A A (1994) Preservation of GLUT 2 expression in islet beta cells of Kilham rat virus (KRV)-infected diabetes-resistant BB/Wor rats. Diabetologia 37:1186-94
Guberski, D L; Butler, L; Manzi, S M et al. (1993) The BBZ/Wor rat: clinical characteristics of the diabetic syndrome. Diabetologia 36:912-9
Ellerman, K; Wrobleski, M; Rabinovitch, A et al. (1993) Natural killer cell depletion and diabetes mellitus in the BB/Wor rat (revisited). Diabetologia 36:596-601
Brown, D W; Welsh, R M; Like, A A (1993) Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats. J Virol 67:5873-8
Barlow, A K; Like, A A (1992) Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat. Am J Pathol 141:1043-51
Like, A A; Guberski, D L; Butler, L (1991) Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes 40:259-62

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